Results 241 to 250 of about 2,452,900 (288)
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Annual Review of Biochemistry, 2004
▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of fundamental physiological importance mediating the actions of the majority of known neurotransmitters and hormones. Opioid receptors are particularly intriguing members of this receptor family.
Waldhoer, Maria +2 more
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▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of fundamental physiological importance mediating the actions of the majority of known neurotransmitters and hormones. Opioid receptors are particularly intriguing members of this receptor family.
Waldhoer, Maria +2 more
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Opioid receptor polymorphismsand opioid abuse [PDF]
Pharmacogenomics, 2002 The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Andrew P. Smith, Nancy M. Lee
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A Biased View of μ-Opioid Receptors?
Molecular Pharmacology, 2019The field of biased agonism has grown substantially in recent years and the μ-opioid receptor has been one of the most intensively studied receptor targets for developing biased agonists.
Alexandra E. Conibear, E. Kelly
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The Journal of Steroid Biochemistry and Molecular Biology, 1994
The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
Siegfried Schwarz, Peter Pohl
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The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
Siegfried Schwarz, Peter Pohl
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Opiate Receptors: Opioid Agonist‐Antagonist Effects
Pharmacotherapy, 1991Two concepts are especially important in understanding the action of agonist‐antagonist opioid analgesics. First, knowing to which receptor classes an agonist‐antagonist binds permits prediction of its pharmacodynamics.
David J. Goldstein, J. Meador-Woodruff
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Fluorescent opioid receptor ligands as tools to study opioid receptor function
Journal of Pharmacological and Toxicological Methods, 2022Opioid receptors are divided into the three classical types: MOP(μ:mu), DOP(δ:delta) and KOP(κ:kappa) that are naloxone-sensitive and an additional naloxone-insensitive nociceptin/orphanin FQ(N/OFQ) peptide receptor(NOP). Studies to determine opioid receptor location and turnover variably rely on; (i) measuring receptor mRNA, (ii) genetically tagging ...
Giakomidi, Despina +4 more
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Opioid receptors and endogenous opioid peptides [PDF]
Medicinal Research Reviews, 1991 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Opioids, Receptors, and Immunity
1993The results achieved by those seeking to determine whether opioids and other drugs of abuse can affect immunity are quite astonishing given the short period of time that research has focused on this area. Despite the fact that there is no longer any question that opioids produce a variety of effects on the immune system, the extent and significance of ...
Martin W. Adler +4 more
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2003
There is little doubt that the use of opiates dates to early human history. There are references to opium in the Ebers Papyrus, and the ancient Sumerians recognized its euphoriant properties when they called the opium poppy the “plant of joy.” Despite millenia of compulsive use and abuse, the opiates are still unrivaled as analgesics, and derivatives ...
Gary J. Brenner, Jianren Mao, Carl Rosow
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There is little doubt that the use of opiates dates to early human history. There are references to opium in the Ebers Papyrus, and the ancient Sumerians recognized its euphoriant properties when they called the opium poppy the “plant of joy.” Despite millenia of compulsive use and abuse, the opiates are still unrivaled as analgesics, and derivatives ...
Gary J. Brenner, Jianren Mao, Carl Rosow
openaire +2 more sources