The mu (µ) and delta (δ) opioid receptors modulate boar sperm motility [PDF]
, 2016 Endogenous and exogenous opioids modulate reproductive functions in target cells via opioid receptors (µ, δ, and κ). Sperm motility is a metric of gamete functionality, and serves as a suitable parameter for in vitro drug-induced toxicity assays.
Alejandro Vicente‐Carrillo +10 more
core +1 more source
Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry
eLife, 2019 Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we developed a fluorescent
Seksiri Arttamangkul +8 more
doaj +1 more source
Frontiers in Physiology, 2023 Opioid medications are the mainstay of pain management but present substantial side-effects such as respiratory depression which can be lethal with overdose.
Jamil Danaf +3 more
doaj +1 more source
Kappa Opioid Regulation of Stress-Related Behavior [PDF]
, 2010 Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression.
Harshberger, Erin
core +1 more source
Atypical opioid receptors: unconventional biology and therapeutic opportunities [PDF]
, 2022 Endogenous opioid peptides and prescription opioid drugs modulate pain, anxiety and stress by activating four opioid receptors, namely μ (mu, MOP), δ (delta, DOP), κ (kappa, KOP) and the nociceptin/orphanin FQ receptor (NOP). Interestingly, several other
Canals, Meritxell +5 more
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Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. [PDF]
PLoS ONE, 2014 Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system
Zi-long Wang +10 more
doaj +1 more source
Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +4 more
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Benzodiazepine receptors and the control of ingestive behaviour in the rat [PDF]
, 1996 When administered systemically, benzodiazepine receptor agonists have been shown to increase food intake in a number of species. Conversely, benzodiazepine receptor inverse agonists bring about reliable decreases in feeding.
Higgs, Suzanne, Higgs, S
core
Pan-Cancer Analysis and Validation of Opioid-Related Receptors Reveals the Immunotherapeutic Value of Toll-Like Receptor 4 [PDF]
, 2023 Shaoping Wu,1 Junnan Chen,1 Enmin Huang,2– 4 Yongfa Zhang1 1Department of Anesthesiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China; 2Biomedical Innovation Center, the Sixth ...
Huang E, Chen J, Zhang Y, Wu S
core
Molecular mechanism of allosteric modulation of opioid receptors
Signal Transduction and Targeted TherapyOpioid analgesics provide potent pain relief but are limited by severe adverse effects, tolerance, and interindividual genetic variability in response. Poly-pharmacology and allosteric modulation of opioid receptors offer promising strategies to enhance ...
Heli Wang +15 more
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