What is the future of targeted therapy in rheumatology: biologics or small molecules? [PDF]
, 2014 Background: Until late in the 20th century, the therapy of rheumatic diseases relied on the use of drugs that had been developed through empirical approaches without detailed understanding of the molecular mechanisms involved.
A Arora +56 more
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Physiological Reports, Volume 13, Issue 18, September 2025.Abstract Altering inflammation can impact the recovering heart's structure and function following myocardial infarction (MI). MAP kinase‐activated protein kinase 2 (MK2) regulates the stability of several pro‐inflammatory cytokines. Hence, this study was to determine if MK2 deficiency impaired the inflammatory phase of post‐MI wound repair.
Joëlle Trépanier +13 more
wiley +1 more source
Identification of genes involved in leukaemia and differentiation induced by activated mutants of the GM-CSF receptor β subunit. [PDF]
, 2005 Interleukin (IL)-3, IL-5 and granulocyte-macrophage-colony-stimulating factor (GM-CSF) are cytokines that affect the growth, survival and differentiation of many cells within the haematopoietic system.
Reynolds, Brenton James
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STAT3 in the systemic inflammation of cancer cachexia [PDF]
, 2016 Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle atrophy and adipose wasting in cachexia; however cachexia is a truly systemic
Bonetto, Andrea +2 more
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Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab [PDF]
, 2015 Multiplexed biomarker analysis showing modulation of Th1/Th2 cytokines, chemokines and growth factors post varlilumab ...
Biwei Zhao +5 more
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Liver cell line derived conditioned medium enhances myofibril organization of primary rat cardiomyocytes [PDF]
, 2016 Cardiomyocytes are the fundamental cells of the heart and play an important role in engineering of tissue constructs for regenerative medicine and drug discovery.
Chung, Alice Mira +4 more
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Catalytic receptors [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
, +11 more
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Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor α increases cyclooxygenase-2 expression, PGErelease and interferon-γ-induced CD40 in murine microglia [PDF]
, 2009 Background Ciliary neurotrophic factor (CNTF) has been regarded as a potent trophic factor for motor neurons. However, recent studies have shown that CNTF exerts effects on glial cells as well as neurons.
Hsiao-Wen Lin +3 more
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Cytokines and the function of the mature nervous system [PDF]
, 1993 In addition to the role that cytokines (growth factors, interleukins, instructive factors) play in regulating neuronal survival, growth and gène expression during development, récent évidence suggests that these intercellular signals can also control ...
Patterson, Paul H.
core
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source