Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure [PDF]
, 2016 Dimeric/oligomeric states of G-protein coupled receptors have been difficult to target. We report here bivalent ligands consisting of two identical oxytocin-mimetics that induce a three order magnitude boost in G-protein signaling of oxytocin receptors ...
Bice Chini +15 more
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The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]
, 2012 Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
core +2 more sources
Is Oxytocin a Contributor to Behavioral and Metabolic Features in Prader–Willi Syndrome?
Current Issues in Molecular BiologyPrader–Willi Syndrome (PWS) is a rare genetic disorder typically characterized by decreased social interaction, hyperphagia, poor behavioral control and temper tantrums, together with a high risk of morbid obesity unless food intake is controlled.
Maria Petersson, Charlotte Höybye
doaj +1 more source
Thyroxine-binding globulin: investigation of microheterogeneity [PDF]
, 1981 Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland +4 more
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The Role of Oxytocin in Polycystic Ovary Syndrome: A Systematic Review
Current Issues in Molecular BiologyPolycystic Ovary Syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age, representing the primary cause of anovulatory infertility.
Nicoletta Cera +2 more
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Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain [PDF]
, 2019 The neural capacity to discriminate between emotions emerges early in development, though little is known about specific factors that contribute to variability in this vital skill during infancy.
Connelly, J. +4 more
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Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
Scientific Reports, 2020 The two hypothalamic neuropeptides oxytocin and melanin concentrating hormone (MCH) share several physiological actions such as the control of maternal care, sexual behavior, and emotions. In this study, we uncover the role for the oxytocin-MCH signaling
Joseph Phan +7 more
doaj +1 more source
Oxytocin receptor is regulated by Peg3
PLOS ONE, 2018 Mouse Peg3 encodes a DNA-binding protein involved in the milk letdown process. In the current study, we tested whether PEG3 controls the expression of the oxytocin receptor gene. According to the results, PEG3 directly binds to a genomic region within the 3rd exon of Oxtr, which contains a DNA-binding motif for PEG3.
Wesley D. Frey +5 more
openaire +4 more sources
Neural correlates of emotion processing comparing antidepressants and exogenous oxytocin in postpartum depressed women: An exploratory study [PDF]
, 2019 Despite common use of antidepressants to treat postpartum depression, little is known about the impact of antidepressant use on postpartum brain activity.
Cheng, Hu +2 more
core +3 more sources
Molecular Aspect of Annelid Neuroendocrine system
, 2007 Hormonal processes along with enzymatic processing similar to that found in vertebrates occur in annelids. Amino acid sequence determination of annelids precursor gene products reveals the presence of the respective peptides that exhibit high sequence ...
Salzet, M.
core +1 more source