Results 291 to 300 of about 4,265,108 (334)
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Non-peptide AT2-receptor agonists
Current Opinion in Pharmacology, 2011The renin-angiotensin-system harbours two main receptor subtypes binding angiotensin II which are the AT1-receptor and the AT2-receptor. While the AT1-receptor has been a drug target in cardiovascular disease for many years, the AT2-receptor was only a subject of academic interest.
U Muscha, Steckelings +8 more
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Peptide hormone and receptor evolution
General and Comparative Endocrinology, 2007An important and fascinating theme that unifies both invertebrate and vertebrate endocrinologists is that of the evolution of peptide precursor and receptor genes. Peptide signalling plays a crucial role in processes that control decisive physiological events in organisms as divergent as yeast and mammals.
Dan, Larhammar, Jozef, Vanden Broeck
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1980
This chapter will critically review attempts to identify receptors for a miscellaneous group of small peptides with apparent multiple roles in the body, only one of which may be that of a neurotransmitter. Most appear to be present in the gut and thus belong to the group of brain-gut peptides (Pearse 1976, 1978).
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This chapter will critically review attempts to identify receptors for a miscellaneous group of small peptides with apparent multiple roles in the body, only one of which may be that of a neurotransmitter. Most appear to be present in the gut and thus belong to the group of brain-gut peptides (Pearse 1976, 1978).
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Molecular imaging targeting peptide receptors
Methods, 2009Overexpressed neuropeptide receptors allow tumor visualization using e.g. radiolabeled peptidic receptor ligands and positron emission tomography (PET) or single photon emission computed tomography (SPECT). This review summarizes the development of radiolabeled probes for peptide receptor imaging since the emergence of the technology with a particular ...
Margret, Schottelius +1 more
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1995
In the past 25 years, a large number of biologically active peptides has been identified in both brain and peripheral tissues. However, our understanding of their role in physiology and disease has been often undermined by the lack of potent and selective antagonists.
William Rostene, Gérard Le Fur
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In the past 25 years, a large number of biologically active peptides has been identified in both brain and peripheral tissues. However, our understanding of their role in physiology and disease has been often undermined by the lack of potent and selective antagonists.
William Rostene, Gérard Le Fur
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Peptide Receptors in the Airways
American Review of Respiratory Disease, 1987Two categories of peptides exert opposing effects on the isolated guinea pig trachea. Neurokinins (substance P [SP] and congeners) provoke contraction, and kinins (bradykinin) provoke relaxation. Both peptide categories promote the release of relaxing prostaglandins that oppose the contractions induced by neurokinins and mediate entirely the ...
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A small peptide modulates stomatal control via abscisic acid in long-distance signalling
Nature, 2018Fuminori Takahashi +8 more
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