Results 91 to 100 of about 444,848 (367)

Essential role for PDGF signaling in ophthalmic trigeminal placode induction [PDF]

, 2008
Much of the peripheral nervous system of the head is derived from ectodermal thickenings, called placodes, that delaminate or invaginate to form cranial ganglia and sense organs.
Bronner-Fraser, Marianne, McCabe, Kathryn L.   +1 more
core   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Purified plasma membranes inhibit polypeptide growth factor-induced DNA synthesis in subconfluent 3T3 cells. [PDF]

, 1984
Plasma membranes derived from NR-6 cells, a variant line of Swiss mouse 3T3 cells that does not have cell surface receptors for epidermal growth factor (EGF), inhibited EGF-induced stimulation of DNA synthesis by 50% in serum-starved, subconfluent 3T3 ...
Fox, CF, Matiuck, NV, Peterson, SW, Vale, RD   +3 more
core  

PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds. [PDF]

, 2014
Topical application of platelet-derived growth factor-BB (PDGF-BB) is considered to accelerate tissue repair of impaired chronic wounds. However, the vast literature is plagued with conflicting reports of its efficacy in animal models and this is often ...
Abbott, Nicholas, Covert, Jill, Dubielzig, Richard, Isseroff, Roslyn, McAnulty, Jonathan, Motta, Monica, Murphy, Christopher, Park, Shin, Raghunathan, Vijay, Schurr, Michael, Shah, Nihar, Teixeira, Leandro   +11 more
core   +2 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor

Italian Journal of Medicine, 2020
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GIST derive from mutations in tyrosine kinase receptors (KIT) or platelet-derived growth factor receptor-α (
Maurizio Alletto, Antonio Burgio, Giovanni Fulco, Giulio Geraci, Concetta Groppuso, Gianfranco Gruttadauria, Elvio Manfrè, Gianluca Mastrosimone, Susanna Salvaggio, Giovanni Urrico, Federico Vancheri   +10 more
doaj  

Mammary tumors that become independent of the type I insulin-like growth factor receptor express elevated levels of platelet-derived growth factor receptors

BMC Cancer, 2011
Background Targeted therapies are becoming an essential part of breast cancer treatment and agents targeting the type I insulin-like growth factor receptor (IGF-IR) are currently being investigated in clinical trials.
Campbell Craig I, Moorehead Roger A
doaj   +1 more source

Possible applications for combined lenvatinib and pembrolizumab in advanced endometrial carcinoma

Креативная хирургия и онкология, 2023
Endometrial cancer is one of the most common gynaecological cancers in both the United States and the Russian Federation, and the rate continues to rise.
K. V. Menshikov, A. V. Sultanbaev, Sh. I. Musin, I. A. Menshikova, N. I. Sultanbaeva, A. A. Izmailov, A. A. Fatikhova, D. O. Lipatov, G. A. Serebrennikov   +8 more
doaj   +1 more source

Autocrine PDGF stimulation in malignancies [PDF]

Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis.
Afrakhte M, Andrae J, Arai H, Armistead PM, Bejcek BE, Betsholtz C, Betsholtz C, Bigner SH, Brennan C, Carl-Henrik Heldin, Clarke ID, Cools J, Deuel TF, Dolloff NG, Ehnman M, Erlandsson A, Ferletta M, Fleming TP, Fredriksson L, Ghanem M, Gotzmann J, Guha A, Hannink M, Heldin C-H, Heldin C-H, Heldin C-H, Hermanson M, Hermanson M, Huang SS, Jechlinger M, Jechlinger M, Johansson FK, Johnsson A, Johnsson A, Kawai T, Keating MT, Kilic T, Kong D, Kumabe T, Lau CK, Lindberg N, Lindblom P, Lokker NA, Magnusson MK, Magnusson MK, Maxwell M, McDermott U, Nistér M, Nistér M, O'Brien KP, Pardanani A, Pietras K, Puputti M, Raines EW, Robson MC, Rodt SÅ, Russell MR, Russell MR, Shimizu A, Simon M-P, Sjöblom T, Smith JS, Smits A, Stürzl M, Swartling FJ, Taniguchi E, Tchougounova E, Tchougounova E, Temin HM, Thiery JP, Todo T, Toffalini F, Uhrbom L, Uhrbom L, Ustach CV, Ustach CV, Valgeirsdóttir S, Vassbotn FS, Wang J, Waterfield MD, Westermark B, Wolf RM   +81 more
core   +2 more sources

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source