Results 121 to 130 of about 444,848 (367)

Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]

, 2019
We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina, Carrera Silva, Eugenio Antonio, Errasti, Andrea Emilse, Gomez, Ricardo Martin, Jenne, Craig N., Mena, Hebe Agustina, Negrotto, Soledad, Olexen, Cinthia Mariel, Ortiz Wilczyñski, Juan Manuel, Schattner, Mirta Ana   +9 more
core   +1 more source

Material Challenges and Alloy Selection for Particle/s‐CO2 Heat Exchangers in Concentrated Solar Power Systems

Advanced Engineering Materials, EarlyView.
Combining supercritical CO2 (s‐CO2) cycles with particle‐based heat transfer media holds great potential in concentrated solar power plants but poses enormous material challenges. The particle/s‐CO2 heat exchanger must withstand extreme conditions, including high temperatures, pressures, CO2 corrosion, and erosion.
Mathias Christian Galetz, Emma Marie Hamilton White, Michael Kerbstadt, Clara Schlereth, Xabier Montero, Daniel Benitez   +5 more
wiley   +1 more source

The Effects of EGF-Receptor Density on Multiscale Tumor Growth Patterns [PDF]

arXiv, 2005
We studied the effects of epidermal growth factor receptor (EGFR) density on tumor growth dynamics, both on the sub- and the multi-cellular level using our previously developed model. This algorithm simulates the growth of a brain tumor using a multi-scale two-dimensional agent-based approach with an integrated transforming growth factor alpha ...
arxiv  

Platelet-derived growth factor receptors in the kidney—Upregulated expression in inflammation

Kidney International, 1989
Major features of a long-standing inflammation in the kidney are vascular proliferation, glomerulosclerosis, interstitial fibrosis and tubular atrophy, leading to a gradual deterioration of the renal function. In this study we have investigated the expression of B-type receptors for platelet-derived growth factor (PDGF) in frozen sections from normal ...
Gunnar Tufveson, Kristoffer Rubin, Carl H. Heldin, Lars Klareskog, Louis Terracio, Lars Rönnstrand, Erik Larsson, Jan Wahlberg, Bengt Fellström   +8 more
openaire   +3 more sources

The role of VEGF receptors in angiogenesis; complex partnerships [PDF]

, 2018
.: Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis but also have profound effects on neural cells. VEGFs are predominantly produced by endothelial, hematopoietic and stromal cells in response to
Ballmer-Hofer, K., Cébe-Suarez, S., Zehnder-Fjällman, A.   +2 more
core  

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source

Dual neovascular targets of vascular endothelial growth factor receptors and platelet‐derived growth factor receptor ameliorate thioacetamide induced liver fibrosis in rats

Portal Hypertension & Cirrhosis
Aims Neovascularization plays a crucial role in liver fibrosis (LF), and blocking vascular endothelial growth factor receptors (VEGFR) has been shown to improve fibrosis. The aim of our study was to investigate the role of dual neovascularization targets,
Bin Xiong, Yaowei Bai, Jiacheng Liu, Tongqiang Li, Yingliang Wang, Chen Zhou   +5 more
doaj   +1 more source

Subretinal fibrosis secondary to neovascular age-related macular degeneration: mechanisms and potential therapeutic targets

Neural Regeneration Research
Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular degeneration. It causes local damage to photoreceptors, retinal pigment epithelium, and choroidal vessels, which leads to permanent central vision loss of patients with ...
Jingxiang Zhang, Xia Sheng, Quanju Ding, Yujun Wang, Jiwei Zhao, Jingfa Zhang   +5 more
doaj   +1 more source

Different functions of the platelet-derived growth factor-alpha and -beta receptors for the migration and proliferation of cultured baboon smooth muscle cells.

Circulation Research, 1994
Migration of medial smooth muscle cells (SMCs) and their proliferation in the intima contribute to thickening of injured and atherosclerotic vessels. These events have been proposed to be regulated in part by platelet-derived growth factor (PDGF).
N. Koyama, C. Hart, A. Clowes
semanticscholar   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source