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Diabetes, 1996
Coronary heart disease is a major complication of diabetic subjects, and platelet-derived growth factor (PDGF) has been implicated in the development of atherosclerosis. We investigated the effects of high glucose on expression of PDGF-β receptor. In a binding assay with 125I-labeled PDGF-BB homodimer, high concentrations of glucose increased high ...
Noritsugu Morino +8 more
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Coronary heart disease is a major complication of diabetic subjects, and platelet-derived growth factor (PDGF) has been implicated in the development of atherosclerosis. We investigated the effects of high glucose on expression of PDGF-β receptor. In a binding assay with 125I-labeled PDGF-BB homodimer, high concentrations of glucose increased high ...
Noritsugu Morino +8 more
openaire +3 more sources
Role of KIT and platelet-derived growth factor receptors as oncoproteins
Seminars in Oncology, 2004KIT and platelet-derived growth factor receptors (PDGFRs) play critical oncogenic roles in a broad spectrum of hematologic and solid tumors. These receptor tyrosine kinases, as well as ABL and BCR-ABL, are inhibited by imatinib. Tumors caused by chromosomal translocations that lead to overexpression of PDGFR ligand, resulting in continuous activation ...
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The Platelet-Derived Growth Factor Receptor
International Journal of Neuroscience, 1985Michael E. Rosenfeld +3 more
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Acta Haematologica, 2008
Rearrangements of the genes encoding the fibroblast growth factor receptor 1 (FGFR1) and platelet-derived growth factor receptors (PDGFR) α or β receptor tyrosine kinases are found in a rare but important subset of patients with atypical myeloproliferative disorders that are usually but not always associated with eosinophilia.
Cross, N.C., Reiter, A.
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Rearrangements of the genes encoding the fibroblast growth factor receptor 1 (FGFR1) and platelet-derived growth factor receptors (PDGFR) α or β receptor tyrosine kinases are found in a rare but important subset of patients with atypical myeloproliferative disorders that are usually but not always associated with eosinophilia.
Cross, N.C., Reiter, A.
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American Journal of Respiratory Cell and Molecular Biology, 2014
Circulating fibrocytes have been reported to migrate into the injured lungs, and contribute to fibrogenesis via CXCL12-CXCR4 axis. In contrast, we report that imatinib mesylate prevented bleomycin (BLM)-induced pulmonary fibrosis in mice by inhibiting platelet-derived growth factor receptor (PDGFR), even when it was administered only in the early phase.
Keisuke Izumi +12 more
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Circulating fibrocytes have been reported to migrate into the injured lungs, and contribute to fibrogenesis via CXCL12-CXCR4 axis. In contrast, we report that imatinib mesylate prevented bleomycin (BLM)-induced pulmonary fibrosis in mice by inhibiting platelet-derived growth factor receptor (PDGFR), even when it was administered only in the early phase.
Keisuke Izumi +12 more
openaire +2 more sources
Platelet-derived growth factor receptor (PDGFR): A target for anticancer therapeutics
Drug Resistance Updates, 2005Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors (PDGFRs) have been implicated in the pathogenesis of a number of tumor types and play an important role in angiogenesis. Tumor growth can be promoted by PDGF via autocrine stimulation of malignant cells, by overexpression or overactivation of PDGFRs, or by stimulation of ...
Board, Ruth, Jayson, Gordon C.
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Journal of Pharmacology and Experimental Therapeutics, 2000
E. Buchdunger +6 more
semanticscholar +1 more source
E. Buchdunger +6 more
semanticscholar +1 more source
Current treatment and recent progress in gastric cancer
Ca-A Cancer Journal for Clinicians, 2021Smita S Joshi, Brian D Badgwell
exaly