Results 61 to 70 of about 444,848 (367)
International Journal of Experimental Pathology, 2011 SummaryPlatelet‐derived growth factor (PDGF) and its receptors (PDGFRs) are strongly involved in the normal development of several organs, tumour angiogenesis and malignant progression and metastasis. Few studies concerning their expression, distribution and role in normal and pathological human thymus are available in the literature.
Anca Maria Cimpean +5 more
openaire +4 more sources
Growth factors and experimental arterial grafts [PDF]
, 2016 Background: The production of growth factors from several experimental arterial conduits was determined. Methods: We implanted 105 experimental arterial grafts that were 1 cm long in the abdominal aorta of Lewis rats (average weight, 250 g).
BORRELLI, Valeria +6 more
core +1 more source
Hydrogen peroxide-inducible clone-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice. [PDF]
PLoS ONE, 2015 Hydrogen peroxide-inducible clone-5 (Hic-5) is a transforming growth factor (TGF)-β1-inducible focal adhesion protein. We previously demonstrated that Hic-5 was localized in mesangial cells and its expression was associated with glomerular cell ...
Ariunbold Jamba +6 more
doaj +1 more source
Fluctuating fitness shapes the clone size distribution of immune repertoires [PDF]
PNAS 113 (2) 274-279 (2016), 2015 The adaptive immune system relies on the diversity of receptors expressed on the surface of B and T-cells to protect the organism from a vast amount of pathogenic threats. The proliferation and degradation dynamics of different cell types (B cells, T cells, naive, memory) is governed by a variety of antigenic and environmental signals, yet the observed
arxiv +1 more source
Isolation and characterization of the platelet-derived growth factor beta receptor promoter [PDF]
Developmental Dynamics, 1997 The PDGFbeta r gene has been implicated in many physiological processes including development and wound healing. Aberrant expression of the receptor is seen in many pathological conditions such as atherosclerosis and inflammatory diseases. To study the mechanisms of PDGFbeta r regulation, we identified the regulatory regions of the gene. We have cloned
Eve Shinbrot +2 more
openaire +3 more sources
Journal of Biological Chemistry, 2002 The Na+/H+exchanger regulatory factor (NHERF) binds through its PDZ1 domain to the carboxyl-terminal sequences NDSLL and EDSFL of the β2adrenergic receptor (β2AR) and platelet-derived growth factor receptor, respectively, and plays a critical role in the
S. Karthikeyan, T. Leung, J. Ladias
semanticscholar +1 more source
Growth factor binding constructs, materials and methods [PDF]
, 2010 The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors. Soluble binding constructs able to bind vascular endothelial
Alitalo, Kari Kustaa +1 more
core
The role of platelet microvesicles in intercellular communication. [PDF]
, 2016 In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as platelet dust by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as ...
Edelstein, Leonard C.
core +2 more sources
Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility [PDF]
, 2015 Cellular functions, ranging from focal adhesion (FA) dynamics and cell motility to tumour growth, are orchestrated by signals cells receive from outside via cell surface receptors.
Browarski, Marietta +9 more
core +4 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source