Results 71 to 80 of about 444,848 (367)
Transplantation Direct, 2018 Background. Nintedanib is a small molecule tyrosine kinase inhibitor that blocks the action of the platelet-derived growth factor receptor (PDGFR), the vascular endothelial growth factor receptor (VEGFR) and the fibroblast growth factor receptor.
Annika Gocht +6 more
doaj +1 more source
The roles of platelet-derived growth factors and their receptors in brain radiation necrosis [PDF]
Radiation Oncology, 2014 Brain radiation necrosis (RN) occurring after radiotherapy is a serious complication. We and others have performed several treatments for RN, using anticoagulants, corticosteroids, surgical resection and bevacizumab. However, the mechanisms underlying RN have not yet been completely elucidated.
Hiroko Kuwabara +8 more
openaire +3 more sources
, 2008 The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors. Soluble binding constructs able to bind vascular endothelial
Alitalo, Kari Kustaa +1 more
core
, 2014 A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core +1 more source
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
BRET biosensor analysis of receptor tyrosine kinase functionality
Frontiers in Endocrinology, 2013 Bioluminescence resonance energy transfer (BRET) is an improved version of earlier resonance energy transfer technologies used for the analysis of biomolecular protein interaction.
Sana eSiddiqui +4 more
doaj +1 more source
Polar Chemoreceptor Clustering by Coupled Trimers of Dimers [PDF]
Biophys J 96(2): 453-463 (2009), 2009 Receptors of bacterial chemotaxis form clusters at the cell poles, where clusters act as "antennas" to amplify small changes in ligand concentration. Interestingly, chemoreceptors cluster at multiple length scales. At the smallest scale, receptors form dimers, which assemble into stable timers of dimers.
arxiv +1 more source
Peptide-Based Targeting of the Platelet-Derived Growth Factor Receptor Beta [PDF]
Molecular Imaging and Biology, 2012 The aim of this work is to identify new ligands targeting the platelet-derived growth factor receptor beta (PDGFRβ).Biopanning was carried out with a 12-amino-acid phage display library against the recombinant extracellular domain of PDGFRβ. The identified peptide PDGFR-P1 was chemically synthesized and labeled with (125)I or (131)I.
Jürgen Debus +7 more
openaire +3 more sources
Mesenchymal stem cells and neovascularization: role of platelet-derived growth factor receptors
Journal of Cellular and Molecular Medicine, 2007 • Introduction • The vascular endothelial growth factor/platelet‐derived growth factor super‐family of ligands and receptors ‐ Vascular endothelial growth factor ligands ‐ Platelet‐derived growth factor ligands ‐ Vascular endothelial growth factor ...
S. Ball, C. Shuttleworth, C. Kielty
semanticscholar +1 more source
Papillomavirus E5: the smallest oncoprotein with many functions [PDF]
, 2011 Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Borzacchiello, G. +6 more
core +4 more sources