Progesterone receptors, their isoforms and progesterone regulated transcription [PDF]
Molecular and Cellular Endocrinology, 2012 This review discusses mechanisms by which progesterone receptors (PR) regulate transcription. We examine available data in different species and tissues regarding: (1) regulation of PR levels; and (2) expression profiling of progestin-regulated genes by total PRs, or their PRA and PRB isoforms.
Britta M, Jacobsen, Kathryn B, Horwitz
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Endometrial Progesterone and Estrogen Receptors in Relation to Hormonal Levels in Women with Unexplained Recurrent Miscarriage [PDF]
Revista Brasileira de Ginecologia e Obstetrícia, 2023 Objective Recurrent miscarriage has been linked to hormonal disturbance due to dysregulation of its receptors rather than to the availability of the hormone.
Ihab Adel Gomaa +4 more
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The Role of Progesterone Receptors in Breast Cancer
Drug Design, Development and Therapy, 2022 The progesterone receptor (PR) modulates estrogen receptors α (ERα) action in breast cancer; it is an upregulated target gene of ER, and its expression is dependent on estrogen.
Zhuoying Li +4 more
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Immunohistochemical expression of progesterone receptor and C-erb-B2 in cervical squamous cell carcinoma and epithelial dysplasia [PDF]
Journal of Clinical and Investigative Surgery, 2021 Objective. We aimed to demonstrate whether the immunohistochemical expression of C-erb-B2 and progesterone receptors are valuable in the diagnosis of intraepithelial cervical neoplasia and squamous cell carcinoma. Methods and Results.
Emine Zeynep Tarini +1 more
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Progestin receptor-mediated reduction of anxiety-like behavior in male rats. [PDF]
PLoS ONE, 2008 BACKGROUND: It is well known progesterone can have anxiolytic-like effects in animals in a number of different behavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular ...
Catherine J Auger, Robin M Forbes-Lorman
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Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer [PDF]
Journal of Pathology and Translational Medicine, 2020 Background Accurate molecular classification of breast core needle biopsy (CNB) tissue is important for determining neoadjuvant systemic therapies for invasive breast cancer.
Ye Sul Jeong +5 more
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Expression of female sex hormone receptors and its relation to clinicopathological characteristics and prognosis of lung adenocarcinoma [PDF]
Journal of Pathology and Translational Medicine, 2020 Background Adenocarcinoma (ADC) of the lung exhibits different clinicopathological characteristics in men and women. Recent studies have suggested that these differences originate from the expression of female sex hormone receptors in tumor cells.
Jin Hwan Lee +2 more
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Immunohistochemical detection of estrogen and progesterone receptors in the human lacrimal gland [PDF]
Archives of Biological Sciences, 2011 The nature and extent of estrogen and progesterone action on the lacrimal gland is not known, and neither are the targets for their action. Immunohistochemical detection of estrogen and progesterone receptors in the human lacrimal glands in both sexes
Gligorijević Jasmina +2 more
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International Journal of Molecular Sciences, 2020 Progesterone and testosterone, beyond their roles as sex hormones, are neuroactive steroids, playing crucial regulatory functions within the nervous system. Among these, neuroprotection and myelin regeneration are important ones.
A. Ghoumari +4 more
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The Neandertal Progesterone Receptor [PDF]
Molecular Biology and Evolution, 2020 Abstract The hormone progesterone is important for preparing the uterine lining for egg implantation and for maintaining the early stages of pregnancy. The gene encoding the progesterone receptor (PGR) carries introgressed Neandertal haplotypes with two missense substitutions and a mobile Alu element.
Hugo Zeberg, Janet Kelso, Svante Pääbo
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