Results 41 to 50 of about 86,670 (263)

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

Expression of estrogen and progesterone receptors in astrocytomas: a literature review

Clinics
Gliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones.
Cléciton Braga Tavares, Francisca das Chagas Sheyla Almeida Gomes-Braga, Danylo Rafhael Costa-Silva, Carla Solange Escórcio-Dourado, Umbelina Soares Borges, Airton Mendes Conde-Junior, Maria da Conceição Barros-Oliveira, Emerson Brandão Sousa, Lorena da Rocha Barros, Luana Mota Martins, Gil Facina, Benedito Borges da-Silva   +11 more
doaj   +1 more source

Correlation of Percentage of Ki67 with Tumor Grade in Breast Cancer

Pakistan Armed Forces Medical Journal, 2023
Objective: To determine the association of Ki67 with tumor grade and other pathological features in patients with breast carcinoma. Study Design: Cross-sectional analytical study.
Aveen Yousuf Khan, Ghulam Haider, Saima Zahoor, Maryum Nouman, Neelma Bukhari   +4 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Characterization of membrane-associated non-genomic progesterone receptors in cattle bull spermatozoa

Indian Journal of Animal Sciences
The present study aimed to examine the molecular existence of the non-genomic progesterone receptors (P4) and their location in Hariana bull spermatozoa.
VIKAS SACHAN, SOUMEN CHOUDHURY, DILIP K SWAIN, ANUJ KUMAR, ATUL SAXENA, PRATISHTHA SHARMA, AVANEESH KUMAR SINGH   +6 more
doaj   +1 more source

Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor

Clinical and Developmental Immunology, 2012
Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility.
Nikolaos Vrachnis, Fotodotis M. Malamas, Stavros Sifakis, Panayiotis Tsikouras, Zoe Iliodromiti   +4 more
doaj   +1 more source

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms

Frontiers in Neuroscience, 2013
Traumatic brain injury is an important and costly medical problem for which no clinically proven treatment currently exists. Studies in rodents and humans have shown beneficial effects of progesterone (P4) on both mortality and functional outcomes ...
Paul S. Cooke
doaj   +1 more source