Results 261 to 270 of about 151,487 (293)

Progesterone receptor coactivators

Steroids, 2000
Progesterone action is mediated by intracellular progesterone receptors that regulate target gene transcription. Recently, numerous proteins termed coactivators have been identified that are recruited by the liganded progesterone receptor and enhance receptor-dependent transactivation.
B G, Rowan, B W, O'Malley
openaire   +2 more sources

Progesterone and progesterone receptors in reptiles

General and Comparative Endocrinology, 2002
The role of progesterone (P) has been most extensively studied in the female reproductive tissues (ovary, reproductive tract, mammary gland) and in the brain, in which it is an important regulator and modulator in conjunction with estradiol (E). In nonmammalian vertebrate species, less work has been done on P metabolites involved in ovulation.
Noemí, Custodia-Lora, Ian P, Callard
openaire   +2 more sources

Progesterone-Progestin Receptors

1974
A correlation between binding to the progestin-specific uterine cytosol receptor and with well-defined facets of progesterone action was established. Structurally similar derivatives of norprogesterone and nortestosterone were compared. Binding was measured in vitro by determining their competitive effect on the progestin-tagged uterine cytosol ...
J P, Raynaud, D, Philibert, G, Azadian-Boulanger   +2 more
openaire   +2 more sources

Progesterone antagonists and progesterone receptor modulators

Expert Opinion on Investigational Drugs, 2003
Since the discovery of the antiprogestin RU 486 (mifepristone), other compounds have been synthesised that function as pure progesterone antagonists or progesterone receptor modulators. The latter are mixed agonists-antagonists. Mifepristone is usually used to terminate pregnancy but these compounds have numerous other applications in female healthcare.
openaire   +2 more sources

Progesterone Receptor Signaling Mechanisms

Journal of Molecular Biology, 2016
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer.
Sandra L, Grimm, Sean M, Hartig, Dean P, Edwards   +2 more
openaire   +2 more sources

Selective progesterone receptor modulators

Current Opinion in Obstetrics & Gynecology, 2014
Review of recent data from clinical trials and descriptions of endometrial morphology with administration of selective progesterone receptor modulators (SPRMs).Recent reports concerning administration of SPRMs, specifically the efficacy of ulipristal acetate in reducing fibroid size and rapid control of menstrual blood loss, have renewed clinical ...
Lucy H R, Whitaker, Alistair R W, Williams, Hilary O D, Critchley   +2 more
openaire   +2 more sources

Novel Mechanisms of Progesterone Antagonists and Progesterone Receptor

Journal of the Society for Gynecologic Investigation, 2000
The progesterone receptor (PR), as a member of the nuclear receptor superfamily of ligand-dependent transcription factors, activates gene transcription through binding to specific palindromic progesterone response elements (PRE) in the promoter region of progestin-responsive genes.
D P, Edwards, S A, Leonhardt, E, Gass-Handel   +2 more
openaire   +2 more sources

Phosphorylation and Progesterone Receptor Function

The Journal of Steroid Biochemistry and Molecular Biology, 1994
Four phosphorylation sites have been identified in the chicken progesterone receptor. Two of these sites exhibit basal phosphorylation which is enhanced upon treatment with hormone and two of the sites are phosphorylated in response to hormone. Mutation of one of these hormone dependent sites, Ser530 to Ala530, causes a decrease in transcriptional ...
N. L. Weigel, W. Bai, Y. Zhang, C. A. Beck, D. P. Edwards, A. Poletti   +5 more
openaire   +3 more sources

Progesterone receptor ligands

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1989
Radiodinated and non-radiodinated 16α-iodo- and 17α-(2-iodovinyl)-19-nortestosterones are prepared and are used in progesterone receptor assays.
Richard Hochberg, William Rosner
openaire   +1 more source

Progesterone Receptor

Nihon rinsho. Japanese journal of clinical medicine, 2006
Tomoko, Shoda, Shuji, Hirata, Kazuhiko, Hoshi, Junzo, Kato   +3 more
  +5 more sources