Results 81 to 90 of about 151,487 (293)

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

CLINICAL CHARACTERISTICS OF BREAST CANCER WITH STEROID RECEPTORS EXPRESSION AND HER2 AMPLIFICATION

Креативная хирургия и онкология, 2017
Since the  middle of the  previous  century  the  heterogeneity of breast cancer  became absolutely evident. This assumption was historically based on differences in clinical behavior and sensitivity to therapy.
F. V. Moiseenko, V. F. Semiglazov, T. Yu. Semiglazova, A. A. Bogdanov, I. E. Eliseev, A. O. Ivantsov, N. А. Knyasev, I. N. Terterov, А. A. Kornev, M. V. Dubina   +9 more
doaj   +1 more source

Progesterone receptor modulators for endometriosis [PDF]

Cochrane Database of Systematic Reviews, 2017
Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of ...
Jing, Fu, Hao, Song, Min, Zhou, Huili, Zhu, Yuhe, Wang, Hengxi, Chen, Wei, Huang   +6 more
openaire   +2 more sources

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Progesterone receptor modulators [PDF]

Journal of Family Planning and Reproductive Health Care, 2010
This letter to the editor discusses the use the primary mechanism of action and the effectiveness of progesterone receptor modulator a ulipristal acetate.
openaire   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Regulation of 3β-Hydroxysteroid Dehydrogenase/∆5-∆4 Isomerase: A Review [PDF]

, 2013
This review focuses on the expression and regulation of 3β-hydroxysteroi ddehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids ...
Abbaszade, Banner, Belanger, Beltowski, Benton, Berchtold, Bo Ekstrand, Brunius, Catalfo, Chapman, Chedrese, Chen, Chen, Cherradi, Clark, Coniglio, Conley, Conley, Conley, Cooke, Couet, Coulter, Cue, Davis, De Launoit, Doran, Doran, Dorgan, Dupont, Fink-Gremmels, Furster, Furster, Galarreta, Galia Zamaratskaia, Garrett, Garrett, Gingras, Gingras, Gromadzka-Ostrowska, Haider, Hassan, Havelock, Headon, Hierlihy, Hild-Petito, Hoog, Hu, Joernvall, Kallberg, Kaynard, Keeney, Keeney, Kershaw, Kiessling, Kostic, Kozlowska, Kumar, Labelle-Dumais, Labrie, LaVoie, Leers-Sucheta, Li, Liang, Lorence, Majdic, Martin, Martin Rasmussen, Mason, Mason, Matsunaga, Mcallister, Meadus, Mizrachi, Mode, Mullany, Nakajin, Nakamura, Naville, Nicolau-Solano, Papacleovoulou, Park, Payne, Payne, Payne, Pelletier, Penning, Picon, Rasmussen, Rasmussen, Rasmussen, Rasmussen, Saez, Samuels, Sasano, Sauer, Shapiro, Siiteri, Simard, Simard, Sirianni, Sordoillet, Stayrook, Sun, Suzuki, Takikawa, Takikawa, Tang, The, Tomankova, Tremblay, Val, Von Teichman, Walstra, Wang, Waxman, Waxman, Wong, Yuan, Zamaratskaia, Zamaratskaia, Zhao, Zinedine   +121 more
core   +2 more sources

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]

, 2020
OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A, Joshi, Suchitra, Kapur, Jaideep, Roden, William H   +3 more
core   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source