Results 1 to 10 of about 6,456 (86)

ATP as a presynaptic modulator [PDF]

open access: yes, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source

Purinergic signaling in the gastrointestinal tract [PDF]

open access: yes, 2011
Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C.
Burnstock, G
core   +2 more sources

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death [PDF]

open access: yes, 2010
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication.
A Gartland   +139 more
core   +2 more sources

Purinergic mechanosensory transduction and visceral pain [PDF]

open access: yes, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources

Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]

open access: yes, 2007
Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma   +3 more
core   +1 more source

Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]

open access: yes, 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter   +4 more
core   +1 more source

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]

open access: yes, 2017
Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi   +12 more
core   +6 more sources

Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release [PDF]

open access: yes, 2017
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in ...
Arnett, T R   +5 more
core   +2 more sources

Purinergic receptor mediated calcium signalling in urothelial cells [PDF]

open access: yes, 2019
Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modulator of bladder mechanosensation. Whilst non-neuronal ATP acts on the underlying bladder afferent nerves to facilitate sensation, there is also the potential for ...
Brierley, Stuart M   +4 more
core   +3 more sources

Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]

open access: yes, 2013
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C.   +4 more
core   +2 more sources

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