Results 1 to 10 of about 14,791 (200)
Purinergic P2 Receptors: Novel Mediators of Mechanotransduction [PDF]
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial role in cellular mechanotransduction.
Qihang Kong +5 more
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Brain Research Bulletin, 2023 Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2. This review discusses whether traditional Chinese medicine target P2 receptors in neuropathic pain and its mechanism in order to provide references for future clinical drug development.
Bo Yang, Nengwei Yu
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Altered Purinergic Signaling in Neurodevelopmental Disorders: Focus on P2 Receptors
Biomolecules, 2023 With the umbrella term ‘neurodevelopmental disorders’ (NDDs) we refer to a plethora of congenital pathological conditions generally connected with cognitive, social behavior, and sensory/motor alterations. Among the possible causes, gestational and perinatal insults have been demonstrated to interfere with the physiological processes necessary for the ...
Marta Boccazzi +4 more
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ATP drives eosinophil effector responses through P2 purinergic receptors
Allergology International, 2015 Eosinophils recognize various stimuli, such as cytokines, chemokines, immunoglobulins, complement, and external pathogens, resulting in their accumulation in mucosal tissues and the progression of inflammation. Eosinophils are also involved in innate Th2-type immune responses mediated through endogenous danger signals, including IL-33, uric acid (UA ...
Takehito Kobayashi +6 more
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Purinergic signalling: past, present and future [PDF]
Brazilian Journal of Medical and Biological Research, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
Burnstock, G
core +3 more sources
Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice [PDF]
Scientific Reports, 2018 AbstractThe functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. Infusion of a non-hydrolysable P2R agonist, ATP-
Chun Yang +8 more
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Role of Nucleotide P2 Receptors in the Immune System: Focus on Effector T Cells. [PDF]
CellsThe emergence of purinergic signaling has given ATP and other extracellular nucleotides a whole new perspective. This concept refers to the fact that extracellular nucleotides released by most cells act as signaling molecules via specific membrane ...
Babou Kammoe RB, Hamoudi C, Aoudjit F.
europepmc +2 more sources
The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease. [PDF]
J Trop MedChagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Pereira CSF, Faria RX.
europepmc +2 more sources
P2 purinergic receptor expression and function in tumor-related immune cells. [PDF]
Purinergic SignalP2 purinergic receptor expression is dysregulated in multiple cancer subtypes and is associated with worse outcomes. Studies identify roles for P2 purinergic receptors in tumor cells that drive disease aggressiveness. There is also sufficient evidence that P2 purinergic receptor expression within the tumor microenvironment (TME) is critical for disease
Manoharan V, Adegbayi OO, Maynard JP.
europepmc +3 more sources
Purinergic Receptors in Dendritic Cells. [PDF]
J Inflamm ResMiaomiao Wang,1 Xiaoxiao Zhao,1 Shuai Hou,1 Zhongbo Wu,2 Hai-yan Yin1 1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Brain Disease Research Center, Tongren People’s ...
Wang M, Zhao X, Hou S, Wu Z, Yin HY.
europepmc +2 more sources