Purinergic Receptors in the Rat Lens: Activation of P2X Receptors following Hyperosmotic Stress
Investigative Opthalmology & Visual Science, 2010 A range of P2Y and P2X receptors is expressed in the rat lens. Because most P2X receptors are located in the cytoplasm, the authors sought to determine whether P2X receptors are functionally active.Rat lenses were cultured under either isotonic or hypertonic conditions in the presence of P2 receptor agonists or antagonists.
Haruna, Suzuki-Kerr +2 more
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Point Mutation in the Mouse P2X Receptor Affects Intercellular Calcium Waves in Astrocytes
ASN Neuro, 2009 Purinergic P2 receptors and gap junctions are two groups of proteins involved in the transmission of ICWs (intercellular calcium waves) between astrocytes.
Sylvia O Suadicani +3 more
doaj +1 more source
Roles of P2 receptors in glial cells: focus on astrocytes [PDF]
, 2006 Central nervous system glial cells release and respond to nucleotides under both physiological and pathological conditions, suggesting that these molecules play key roles in both normal brain function and in repair after damage.
Maria P. Abbracchio +64 more
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Cannabinoid receptors contribute to astroglial Ca2+-signalling and control of synaptic plasticity in the neocortex [PDF]
, 2014 Communication between neuronal and glial cells is thought to be very important for many brain functions. Acting via release of gliotransmitters, astrocytes can modulate synaptic strength.
Lalo, Ulyana +3 more
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Functional Role of Spliced Cytoplasmic Tails in P2X2-Receptor-Mediated Cellular Signaling
Journal of Pharmacological Sciences, 2006 .: P2X receptors belong to a unique family of ligand-gated channels in terms of their molecular architecture, in which the channel subunit has two transmembrane alpha-helixes with a large extracellular loop keeping amino- and carboxy-termini in the ...
Koshimizu Taka-aki, Tsujimoto Gozoh
doaj +1 more source
Functional maturation of isolated neural progenitor cells from the adult rat hippocampus [PDF]
, 2004 Although neural progenitor cells (NPCs) may provide a source of new neurons to alleviate neural trauma, little is known about their electrical properties as they differentiate.
Chipperfield H. +15 more
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P2X₃ Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP [PDF]
, 2001 The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X₃ receptor knock-out (P2X₃ ⁻⁄⁻) and wild-type control (P2X₃ ⁺⁄⁺) mice.
Bardini, M +7 more
core
Isolation and characterization of Pisum sativum apyrases, PsNTP9 and PsNTP9-DM, cloned and expressed in Escherichia coli [PDF]
, 2019 Adenosine triphosphate (ATP) is widely known as a fuel source for many biochemical processes, and to a lesser degree also as a signaling molecule in plants and animals.
Wallen, Michael Andrew, Jr
core +1 more source
Nitric oxide modulates ATP-evoked currents in mouse Leydig cells
Brazilian Journal of Medical and Biological Research, 2018 Testosterone synthesis within Leydig cells is a calcium-dependent process. Intracellular calcium levels are regulated by different processes including ATP-activated P2X purinergic receptors, T-type Ca2+ channels modulated by the luteinizing hormone, and ...
J.L. de Deus +2 more
doaj +1 more source
P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. [PDF]
, 2012 The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively expressed in neurons and glia in the brain. Activation of the P2X7 receptor has been found to modulate neuronal excitability in the hippocampus and it has ...
Diaz-Hernandez, Miguel +4 more
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