Results 111 to 120 of about 15,256 (224)

Functional characterization of P2Y1 and P2X4 receptors in human neuroblastoma SK-N-MC cells [PDF]

, 2015
Nucleotides are important signalling molecules in both the peripheral and central nervous system. However, the in vitro study of their receptors can be hampered by the heterogeneity of primary neuronal cultures. The use of clonal neuroblastoma cell lines
Bullido, María Jesús, Gualix, Javier, León-Otegui, Miriam, Miras-Portugal, M. Teresa, Recuero, Maria, Valdivieso, Fernando   +5 more
core   +1 more source

P2X receptor-mediated ATP purinergic signaling in health and disease

Cell Health and Cytoskeleton, 2012
Purinergic P2X receptors are plasma membrane proteins present in a wide range of mammalian cells where they act as a cellular sensor, enabling cells to detect and respond to extracellular adenosine triphosphate (ATP), an important signaling molecule. P2X receptors function as ligand-gated Ca 2+ -permeable cationic channels that open upon ATP binding to
openaire   +2 more sources

Activation of Adenosine Triphosphate-Gated Purinergic 2 Receptor Channels by Transient Receptor Potential Vanilloid Subtype 4 in Cough Hypersensitivity

Biomolecules
Background: Transient receptor potential vanilloid subtype 4 (TRPV4) is a Ca2+-permeable non-selective cation channel that is involved in the development of cough hypersensitivity. Purinergic 2 receptors (P2X) belong to a class of adenosine triphosphate (
Wanzhen Li, Shengyuan Wang, Tongyangzi Zhang, Yiqing Zhu, Li Yu, Xianghuai Xu   +5 more
doaj   +1 more source

Differences in localization of P2X7 during epithelial wound healing in pre-type II diabetic models [PDF]

, 2017
Corneal injury, accompanied by improper wound repair, is the 4th highest cause of preventable blindness according to the World Health Organization.
Kneer, Krisandra
core  

Purinergic P2X receptor 7 (P2X7R) inhibition induced cytotoxicity in glioblastoma

PLOS One
Glioblastoma is the most common and aggressive form of primary brain cancer with a median survival of 15 months from diagnosis. The purinergic receptor P2X7 (P2X7R) is a regulator of several cell signalling pathways, and its expression is upregulated in glioblastoma.
Matthew Drill, Liyen Katrina Kan, Richard P. Sequeira, Padmakrishnan Chorakode Jayakrishnan, Martin Hunn, Nigel C. Jones, Terence J. O’Brien, Mastura Monif   +7 more
openaire   +1 more source

Facilitation of Neurotransmitter and Hormone Release by P2X Purinergic Receptors

, 2012
Nucleotides are emerging as ubiquitous family of extracellular signaling molecules. Their effects are mediated through a specific class of plasma membrane receptors called purinergic P2 receptors that, according to the molecular structure, are further subdivided into two subfamilies: P2Y and P2X. Specifically, P2X receptors (P2XRs) are ligand-gated ion
Vavra, Vojtech, Bhattacharya, Anirban, Jindrichova, Marie, Zemkova, Hana   +3 more
openaire   +3 more sources

Identification of P2X₃ and P2X₇ purinergic receptors activated by ATP in rat lacrimal gland.

Investigative ophthalmology & visual science, 2011
PURPOSE. To identify the type of purinergic receptors activated by adenosine triphosphate (ATP) in rat lacrimal gland and to determine their role in protein secretion. METHODS. Purinergic receptors were identified by RT-PCR, Western blot analysis, and immunofluorescence techniques.
Robin R, Hodges, Joanna, Vrouvlianis, Rachel, Scott, Darlene A, Dartt   +3 more
openaire   +1 more source

Neurotransmitter signaling in white matter [PDF]

, 2014
Butt, Arthur M., Fern, Robert F., Matute, Carlos   +2 more
core   +1 more source

Latest advances on the role of P2X Receptors in colorectal inflammation and cancer. [PDF]

Purinergic Signal
Ruo L, Fortuna F, Grignolo M, Pegoraro A, Adinolfi E.   +4 more
europepmc   +1 more source

Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors. [PDF]

Purinergic Signal
Chaves MM, Carvalho-Barbosa N, Savio LEB, Coutinho-Silva R.   +3 more
europepmc   +1 more source