Results 181 to 190 of about 15,256 (224)
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Molecular Dissection of Purinergic P2X Receptor Channels
Annals of the New York Academy of Sciences, 2005Abstract: The P2X receptors (P2XRs) are a family of ATP‐gated channels expressed in the plasma membrane of numerous excitable and nonexcitable cells and play important roles in control of cellular functions, such as neurotransmission, hormone secretion, transcriptional regulation, and protein synthesis.
Stanko S, Stojilkovic +5 more
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P2X purinergic receptor ligands: recently patented compounds
Expert Opinion on Therapeutic Patents, 2010P2X channels are ionotropic purinergic receptors that are currently under scrutiny as attractive targets for novel therapeutics in areas including chronic inflammation, pain and depression. Their wide expression in the CNS, recent advances in the biochemical and pharmacological properties as well as increasing numbers of patents published in this ...
Gunosewoyo, Hendra, Kassiou, M.
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Assembly and trafficking of P2X purinergic receptors (Review)
Molecular Membrane Biology, 2008P2X receptors are cation selective ion channels gated by the binding of extracellular ATP. Seven subtypes have been identified and they have widespread and overlapping distributions throughout the body. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization.
Ruth D, Murrell-Lagnado, Omar S, Qureshi
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P2X (Purinergic) receptor distributions in rat blood vessels
Journal of the Autonomic Nervous System, 1999The distribution of purinergic (P2X1 and P2X2) receptors on smooth muscle cells in relation to autonomic nerve varicosities in rat blood vessels has been determined using immunofluorescence and confocal microscopy. P2X1 and P2X2 receptors were visualised using rabbit polyclonal antibodies against the extracellular domain of the receptors and ...
Hansen, M. A. +4 more
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Distribution of purinergic P2X receptors in the rat heart
Journal of the Autonomic Nervous System, 1999The distribution of P2X purinergic receptor subtypes has been determined in relation to nerve varicosities in the rat heart with immunohistochemistry. Large clusters (about 1 microm diameter) of co-localised and sometimes co-extensive P2X1 and P2X3 receptors were found at sites of tyrosine hydroxylase (TH) positive axon varicosities in the atrium and ...
M A, Hansen, M R, Bennett, J A, Barden
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Editorial overview: Purinergic P2X receptors in innate immunity and inflammation
Current Opinion in Pharmacology, 2019No abstract ...
Di Virgilio F., Pelegrin P.
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Purinergic P2X receptors: Structural models and analysis of ligand-target interaction
European Journal of Medicinal Chemistry, 2015The purinergic P2X receptors are ligand-gated cation channels activated by the endogenous ligand ATP. They assemble as homo- or heterotrimers from seven cloned subtypes (P2X1-7) and all trimer subunits present a common topology consisting in intracellular N- and C- termini, two transmembrane domains and a large extracellular domain.
DAL BEN, DIEGO +5 more
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Purinergic P2X Receptors as Therapeutic Targets
Purinergic P2X receptors are ATP-gated ion channels involved in cation flux across membranes. P2X receptors are assembled as trimers from three identical subunits (homomeric) or from a combination of subunits (heteromeric) and display different biophysical and pharmacological properties.Stokes, Leanne +2 more
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Purinergic P2X, P2Y and adenosine receptors differentially modulate hippocampal gamma oscillations
Neuropharmacology, 2012The present study was designed to investigate the role of extracellular ATP and its receptors on neuronal network activity. Gamma oscillations (30-50 Hz) were induced in the CA3 region of acute rat hippocampal slices by either acetylcholine (ACh) or kainic acid (KA).
Steffen B, Schulz +4 more
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Functional ligand-gated purinergic receptors (P2X) in rat vestibular ganglion neurons
Hearing Research, 2010The expression of purinergic receptors (P2X) on rat vestibular ganglion neurons (VGNs) was examined using whole-cell patch-clamp recordings. An application of adenosine 5'-triphosphate (ATP; 100microM) evoked inward currents in VGNs at a holding potential of -60mV.
Ken, Ito +5 more
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