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Role of the purinergic P2X receptors in osteoclast pathophysiology
Current Opinion in Pharmacology, 2019Osteoclasts are cells of the hematopoietic lineage that are responsible for bone resorption. Their activity is crucial in the initiation of bone remodeling and for maintenance of a strong and healthy skeleton. However, in a number of diseases, including inflammatory disorders, inappropriately high osteoclast activity results in excessive bone ...
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Regulation of P2X Purinergic Receptor Signaling by Cholesterol
2017P2X receptors are cation-selective channels that are activated by the binding of extracellular ATP. They have a high permeability to Ca2+, Na+, and K+ and are expressed widely throughout the nervous, immune, cardiovascular, skeletal, gastrointestinal, respiratory, and endocrine systems.
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P2X purinergic receptor channel expression and function in bovine aortic endothelium
American Journal of Physiology-Heart and Circulatory Physiology, 2002We examined bovine aortic endothelial cells (BAECs) for the functional expression of P2X receptors, the ATP-gated cation channels. We identified the P2X subtypes present in BAECs using RT-PCR. mRNA was present for only three of seven family members: P2X4, P2X5, and P2X7.
Angelina N, Ramirez, Diana L, Kunze
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Purinergic P2X receptors and diabetic neuropathic pain.
Sheng li xue bao : [Acta physiologica Sinica], 2015Diabetic peripheral neuropathy (DPN), one of the most common chronic complications of diabetes, is characterized by allodynia, hyperalgesia and spontaneous pain. Chinese epidemiological studies have shown that at least 25% diabetic patients suffered from painful DPN, which compromises patients' daily functioning and becomes a major health care problem.
Lei, Shi +4 more
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Participation of Purinergic P2X Receptors in the Thermoregulatory Response to Cooling
Bulletin of Experimental Biology and Medicine, 2017We studied the role of purinergic P2X receptors in the body response to cooling. In experiments on rats, P2X receptor antagonist PPADS was administered in different modes, which resulted in changes of different characteristics of the thermoregulatory response to cold. Iontophoresis of P2X antagonist into the skin decreased the thermal thresholds of all
T V, Kozyreva, E S, Meyta, V P, Kozaruk
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Distribution of P2Y and P2X purinergic receptor expression within the intestine
American Journal of Physiology-Gastrointestinal and Liver PhysiologySeveral studies have revealed crucial roles for P2 receptors during inflammatory and infectious diseases, however, these have largely been demonstrated in immune cells and the enteric nervous system. Although epithelial cells serve as the first barrier against infection and inflammation, the role of purinergic signaling within the gastrointestinal ...
Kristen A. Engevik +5 more
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Extracellular ATP-Gated P2X Purinergic Receptor Channels
2003Publisher Summary This chapter discusses the aspects of extracellular adenosine triphosphate (ATP)-gated P2X purinergic receptor channels. It was known for decades that the application of ATP as an extracellular agonist on a cell or tissue led to the permeabilization of the cell plasma membrane.
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Neuropharmacology, 2016
The role of purinergic signaling in human ENS is not well understood. We sought to further characterize the neuropharmacology of purinergic receptors in human ENS and test the hypothesis that endogenous purines are critical regulators of neurotransmission.LSCM-Fluo-4/(Ca(2+))-imaging of postsynaptic Ca(2+) transients (PSCaTs) was used as a reporter of ...
A, Liñán-Rico +11 more
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The role of purinergic signaling in human ENS is not well understood. We sought to further characterize the neuropharmacology of purinergic receptors in human ENS and test the hypothesis that endogenous purines are critical regulators of neurotransmission.LSCM-Fluo-4/(Ca(2+))-imaging of postsynaptic Ca(2+) transients (PSCaTs) was used as a reporter of ...
A, Liñán-Rico +11 more
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Purinergic receptor P2X₇: a novel target for anti-inflammatory therapy.
Bioorganic & medicinal chemistry, 2014Purinergic receptors, also known as purinoceptors, are ligand gated membrane ion channels involved in many cellular functions. Among all identified purinergic receptors, P2X₇ subform is unique since it induces the caspase activity, cytokine secretion, and apoptosis.
Nisha, Mehta +7 more
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