Results 61 to 70 of about 15,256 (224)

Control of Macrophage Inflammation by P2Y Purinergic Receptors

Cells, 2021
Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity.
Dominik Klaver, Martin Thurnher
doaj   +1 more source

Understanding the role of P2X7 in affective disorders—are glial cells the major players? [PDF]

, 2015
Pathophysiology associated with several psychiatric disorders has been linked to inflammatory biomarkers. This has generated a theory of major depressive disorders as an inflammatory disease.
Jenkins, Trisha A., Spencer, Sarah J., Stokes, Leanne   +2 more
core   +2 more sources

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, EarlyView.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Activation of adenosine A_2B receptors enhances ciliary beat frequency in mouse lateral ventricle ependymal cells

Cerebrospinal Fluid Research, 2009
Background Ependymal cells form a protective monolayer between the brain parenchyma and cerebrospinal fluid (CSF). They possess motile cilia important for directing the flow of CSF through the ventricular system.
Ravid Katya, Yang Dan, Genzen Jonathan R, Bordey Angelique   +3 more
doaj   +1 more source

Role of purinergic P2X receptors in the control of liver homeostasis [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractIt is now accepted that extracellular ATP and other nucleotides are potent signaling molecules, akin to neurotransmitters, hormones, and lipid mediators. In the liver, several clues support a significant role for extracellular ATP‐induced signaling pathways in the control of tissue homeostasis.
Michel, Fausther, Emmanuel, Gonzales, Jonathan A, Dranoff   +2 more
openaire   +2 more sources

P2X7 Receptor Mediated Increase In Cell Membrane Permeability

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2018
Purinergic receptors consist of two main families; P2X and P2Y. P2Y receptors are G protein coupled receptors (GPCR), whereas P2X receptors are non-selective cation channels. P2X7 receptors which is a member of P2X receptors, have been found myriad types
Șerife Cankurtaran-Sayar, Kemal Sayar
doaj   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Pharmacologic P2X purinergic receptor antagonism in the treatment of collagen‐induced arthritis [PDF]

Arthritis & Rheumatism, 2011
AbstractObjectiveTo assess the therapeutic potential of a P2X purinergic receptor antagonist, namely, periodate oxidized ATP, in collagen‐induced arthritis (CIA).MethodsArthritis was induced in male DBA/1J mice by immunization with type II collagen (CII).
V. Ardissone, E. Radaelli, P. Zaratin, M. Ardizzone, C. Ladel, M. Gattorno, A. Martini, F. Grassi, E. Traggiai   +8 more
openaire   +2 more sources

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Pharmacology of P2X Receptors and Their Possible Therapeutic Potential in Obesity and Diabetes

Pharmaceuticals
The role of P2X ionotropic receptors in the behavior of purinergic signaling on pathophysiological processes has been widely studied. In recent years, the important participation of P2X receptors in physiological and pathological processes, such as ...
Guillermo A. Cabral-García, José R. Cruz-Muñoz, Eduardo E. Valdez-Morales, Alma Barajas-Espinosa, Andrómeda Liñán-Rico, Raquel Guerrero-Alba   +5 more
doaj   +1 more source