Results 81 to 90 of about 15,256 (224)

P2X7 receptors induce degranulation in human mast cells. [PDF]

, 2016
Mast cells play important roles in host defence against pathogens, as well as being a key effector cell in diseases with an allergic basis such as asthma and an increasing list of other chronic inflammatory conditions.
A Lundequist, A Surprenant, AG Driver, AM Gilfillan, AS Kirshenbaum, AW Hauswirth, B Hechler, C Feng, CE Owen, D Ferrari, DM Manthei, E Shigetomi, Elizabeth P. Seward, ES Schulman, F Jacob, F Virgilio Di, G Barbara, G Buell, G Burnstock, G Burnstock, H Saito, J Capite Di, JM Brown, JP Bennett, K Mulryan, K Wareham, Kathryn J. Wareham, M Idzko, M Idzko, M Vig, MA McCloskey, MG Rolf, N Sudo, OK Basoglu, PE Tatham, R Dahlquist, R Dahlquist, RC Wykes, RJ Evans, SR Holdsworth, TM Egan, Y Kurashima, Y Osipchuk, ZG Gao   +43 more
core   +1 more source

Spatio‐Temporal Diversity of Calcium Activity in Microglia

Glia, Volume 74, Issue 3, March 2026.
Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi, Dennis Lawrence Cheung, Junko Ishida, Junichi Nabekura   +3 more
wiley   +1 more source

Expression of Purinergic and Endothelial Activation Markers in Brain Tissue From Fatal Microcephaly Associated With ZIKV

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Zika virus (ZIKV) is a flavivirus that has gained global attention due to its association with congenital microcephaly and neuroinflammatory responses. Markers of endothelial activation and purinergic signaling have been identified in the context of ZIKV neuropathogenesis, although the underlying mechanisms remain poorly understood.
Jorge Rodrigues de Sousa, Gustavo Batista Ferro, Leticia Vieira Teixeira, Carlos Silva, Ligia Lima, Orlando Neto, Raimunda Azevedo, Jannifer Oliveira Chiang, Livia Medeiros Neves Casseb, Arnaldo Jorge Martins Filho, Lívia Caricio Martins, Juarez Antônio Simões Quaresma, Pedro Fernando da Costa Vasconcelos   +12 more
wiley   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, Volume 111, Issue 3, Page 1524-1542, 1 March 2026.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Bradykinin Contributes to Sympathetic and Pressor Responses Evoked by Activation of Skeletal Muscle Afferents P2X in Heart Failure

Cellular Physiology and Biochemistry, 2016
Background/Aims: Published data suggest that purinergic P2X receptors of muscle afferent nerves contribute to the enhanced sympathetic nervous activity (SNA) and blood pressure (BP) responses during static exercise in heart failure (HF).
Jihong Xing, Jianhua Li
doaj   +1 more source

Mechanisms Underlying Purinergic P2X3 Receptor-Mediated Mechanical Allodynia Induced in Diabetic Rats [PDF]

, 2011
Background Diabetic neuropathy is a common neuropathy associated with paresthaesia and pain. The mechanisms underlying the painful conditions are not well understood.
Guang-Yin Xu, Guangwen Li, Ningang Liu, Li-Yen Huang, Xu, Guang-Yin   +4 more
core   +2 more sources

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Novel Technologies for Exploring the Skin–Brain Axis

Advanced Sensor Research, Volume 5, Issue 2, February 2026.
The skin–brain axis mediates bidirectional communication between cutaneous physiology and the nervous system, influencing sensation, inflammation, and disease. This review surveys emerging microsensor, nanosensor, and bioelectronic technologies integrated with advanced skin and neural models, highlighting multimodal, real‐time strategies to decode ...
Dahiana Mojena Medina, Francesca Santoro
wiley   +1 more source

Purinergic signalling in bone

Frontiers in Endocrinology, 2012
Purinergic signalling in bone was first proposed in the early 1990s with the observation that extracellular ATP could modulate events crucial to the normal functioning of bone cells.
Robin Mark Howard Rumney, Ning eWang, Ankita eAgrawal, Alison eGartland   +3 more
doaj   +1 more source

Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. [PDF]

, 2012
BACKGROUND: Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. METHODS: Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp ...
Blackman, Michael J, Budu, Alexandre, Cruz, Laura Nogueira, Garcia, Célia Rs, Holder, Anthony A, Juliano, Luiz, Juliano, Maria Aparecida   +6 more
core   +4 more sources