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RETINOIC ACID RECEPTORS AND CANCERS [PDF]
Annual Review of Nutrition, 2004 ▪ Abstract Studies utilizing experimental animals, epidemiological approaches, cellular models, and clinical trials all provide evidence that retinoic acid and some of its synthetic derivatives (retinoids) are useful pharmacological agents in cancer therapy and prevention.
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Retinoic acid and retinoic acid receptors in development
Molecular Neurobiology, 1995The vitamin A derivative retinoic acid (RA) and related compounds (retinoids) are utilized as signaling molecules in a diverse array of developmental and physiological regulatory processes, including many important in the developing and mature nervous system. Retinoids function by interaction with high affinity receptors of the nuclear receptor family,
Ronald M. Evans, Henry M. Sucov
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Retinoic acid and retinoic acid receptors in craniofacial development
Seminars in Cell & Developmental Biology, 1997Interest in retinoids and craniofacial development originated independently from nutritional and teratological studies; however, the site of action of retinoids in normal development remains contentious. Recent transgenic strategies have shown that retinoic acid and nuclear retinoid receptors are required for the morphogenetic specification of cranial ...
Paul M. Brickell, Peter Thorogood
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The Retinoic Acid Receptors [PDF]
, 2015 Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
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Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling
2014Retinoic acid (RA) is a vitamin A-derived morphogen controlling important developmental processes in vertebrates, and more generally in chordates, including axial patterning and tissue formation and differentiation. In the embryo, endogenous RA levels are controlled by RA synthesizing and degrading enzymes and the RA signal is transduced by two ...
Gutierrez-Mazariegos, Juliana +2 more
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History of Retinoic Acid Receptors
2014The discovery of retinoic acid receptors arose from research into how vitamins are essential for life. Early studies indicated that Vitamin A was metabolized into an active factor, retinoic acid (RA), which regulates RNA and protein expression in cells.
Cécile Rochette-Egly +3 more
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Developmental roles of the retinoic acid receptors
The Journal of Steroid Biochemistry and Molecular Biology, 1995Retinoic acid, one of the principle active metabolites of vitamin A (retinol), is believed to be essential for numerous developmental and physiological processes. Vitamin A deprivation (VAD) during development leads to numerous congenital defects. Previous studies of retinoic acid receptor (RAR) deficient mice failed to reveal any of these VAD-induced ...
Lohnes, David +8 more
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Retinoic Acid Receptors in Hematopoiesis
1996Retinoic acid receptors (RARs) are critical transcriptional regulators that are involved in the development and differentiation of a wide variety of different cells (Evans 1988). Several lines of evidence suggest that RARs may be involved in the regulation of hematopoiesis.
Irwin D. Bernstein +2 more
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