Results 81 to 90 of about 49,849 (243)

Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease

Mediators of Inflammation, 2013
It is widely accepted that cells serving immune functions in the brain, namely, microglia and astrocytes, are important mediators of pathological phenomena observed in Alzheimer’s disease. However, it is unknown how these cells initiate the response that
Francisca Cornejo, Rommy von Bernhardi
doaj   +1 more source

Hollow‐Structured Nanorobot with Excellent Magnetic Propulsion for Catalytic Pollutant Degradation, Anti‐Bacterial and Biofilm Removal

Advanced Healthcare Materials, EarlyView.
A hollow‐structured Fe3O4@AgAu@PDA‐ZnPc nanosphere has been developed, exhibiting controllable catalytic activity and “photothermal‐photodynamic‐Ag+” coupling antibacterial characteristics. When subjected to a rotating magnetic field, these performances are uniquely enhanced by magnetic propulsion, allowing the nanosphere to function as a magnetic ...
Jing Wang, Guangjin Yu, Qunling Fang, Yunqi Xu, Jie Zhang, Ailing Hui, Shouhu Xuan, Ken Cham‐Fai Leung   +7 more
wiley   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Scavenger Receptor A: A New Route for Adenovirus 5

Molecular Pharmaceutics, 2009
Adenoviruses are common pathogens associated with respiratory diseases, gastrointestinal illnesses and/or conjunctivitis. Currently, this virus is used as a vector in gene therapy trials. The promise of viral gene therapy applications is substantially reduced because the virus is cleared by liver macrophages upon systemic administration.
Haisma, H, Boesjes, M, Beerens, A, van der Strate, B, Curiel, D, Plüddemann, A, Gordon, S, Bellu, A   +7 more
openaire   +3 more sources

Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI

Journal of Lipid Research, 2007
Modified forms of LDL, including oxidized low density lipoprotein (OxLDL), contribute to macrophage lipid accumulation in the vessel wall. Despite the pathophysiological importance of uptake pathways for OxLDL, the molecular details of OxLDL endocytosis ...
Bing Sun, Boris B. Boyanovsky, Margery A. Connelly, Preetha Shridas, Deneys R. van der Westhuyzen, Nancy R. Webb   +5 more
doaj  

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Macrophage Scavenger Receptors and Atherosclerosis

The journal of the Japanese Society of Lymphoreticular Tissue research, 1998
A hallmark of atherosclerosis is the deposition of plasma cholesterol in atherosclerotic plaques in arterial walls. Key cellular components of atherosclerotic plaques are foam cells, which are derived from monocytes-macrophages. In order to elucidate the molecular mechanism of foam cell formation, we cloned and characterized cDNA for type I and II MSR.
openaire   +3 more sources

Macrophage Recognition of Crystals and Nanoparticles

Frontiers in Immunology, 2018
Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis ...
Masafumi Nakayama, Masafumi Nakayama
doaj   +1 more source

Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers

Advanced Healthcare Materials, EarlyView.
The presence of residual tumors after ablative therapies poses a significant challenge, generally resulting in recurrence and metastases. This review offers a concise overview of immune‐inducible biomaterials from the perspective of the cancer‐immunity cycle, and how they enhance antitumor immunity through diverse mechanisms following ablative ...
Shuangshuang Zhao, Zheng Zhang, Xincai Wu, Yanwei Chen, Wenjun Li, Jiayan Bao, Xin Zhang, Baoding Chen   +7 more
wiley   +1 more source

Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1

MicrobiologyOpen, 2019
The histamine H2 receptor (H2R) is a G protein‐coupled receptor that mediates cyclic AMP production, protein kinase A activation, and MAP kinase signaling.
Robert Fultz, Melinda A. Engevik, Zhongcheng Shi, Anne Hall, Beatrice Herrmann, Bhanu P. Ganesh, Angela Major, Anthony Haag, Yuko Mori‐Akiyama, James Versalovic   +9 more
doaj   +1 more source