Results 21 to 30 of about 2,570,395 (251)

Expression of Serotonin Receptors in Bone [PDF]

Journal of Biological Chemistry, 2001
The 5-hydroxytryptamine (5-HT) receptors 5-HT(2A), 5-HT(2B), and 5-HT(2C) belong to a subfamily of serotonin receptors. Amino acid and mRNA sequences of these receptors have been published for several species including man. The 5-HT(2) receptors have been reported to act on nervous, muscle, and endothelial tissues.
Westbroek, I., van der Plas, A., de Rooij, K., Klein Nulend, J., Nijweide, P.J.   +4 more
openaire   +4 more sources

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Boer, Sietse F. de,, Buwalda, Bauke,, Jong, Jelly G. de,, Koolhaas, Jaap M.,, Ruiter, Anne J.H. de,, Vegt, Bea J. van der,   +5 more
core   +1 more source

Classification of Serotonin Receptors

Journal of Cardiovascular Pharmacology, 1987
The subdivision of serotonin (5-HT) receptors into three classes, designated 5-HT1, 5-HT2, and 5-HT3, has been based on radioligand binding studies and experiments in isolated tissues. As a result of radioligand binding studies, two types of 5-HT recognition sites have been postulated. One site specifically labeled by [3H]5-HT was termed 5-HT1, and the
Manfred Göthert, Eberhard Schlicker
openaire   +4 more sources

Structural insights into lipid and ligand regulation of serotonin receptors

Nature, 2019
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms1 by synchronization to environmental cues and is involved in diverse physiological processes2 such as the regulation of blood pressure and core body temperature ...
B. Stauch, L. Johansson, J. McCorvy, N. Patel, G. Han, Xi-Ping Huang, C. Gati, A. Batyuk, Samuel T. Slocum, A. Ishchenko, W. Brehm, T. White, N. Michaelian, C. Madsen, Lan Zhu, T. Grant, J. Grandner, A. Shiriaeva, Reid H. J. Olsen, A. Tribo, S. Yous, R. Stevens, U. Weierstall, V. Katritch, B. Roth, Wei Liu, V. Cherezov   +26 more
semanticscholar   +1 more source

Serotonin 2a Receptor and Serotonin 1a Receptor Interact Within the Medial Prefrontal Cortex During Recognition Memory in Mice [PDF]

, 2015
Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it.
Gaël eMalleret, Jay eGingrich, Jay eGingrich, Juan Facundo Morici, Lucia eCiccia, Noelia eWeisstaub, Pedro eBekinschtein   +6 more
core   +2 more sources

Serotonin and brain function: a tale of two receptors

Journal of Psychopharmacology, 2017
Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the ...
RL Carhart-Harris, D. Nutt
semanticscholar   +1 more source

The Serotonin Receptor Subtype 5b Specifically Interacts with Serotonin Receptor Subtype 1A [PDF]

Frontiers in Molecular Neuroscience, 2017
Previously, we described the dysregulation of serotonin (5-HT) receptor subtype 5b (5-ht5b) in a mouse model of Rett syndrome (RTT). 5-ht5b has not been extensively studied, so we set out to characterize it in more detail. Unlike common cell surface receptors, 5-ht5b displays no membrane expression, while receptor clusters are located in endosomes ...
Sabine Niebert, Gijsbert J. van Belle, Steffen Vogelgesang, Steffen Vogelgesang, Till Manzke, Till Manzke, Marcus Niebert, Marcus Niebert   +7 more
openaire   +4 more sources

Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks

Nature Neuroscience, 2022
Although we understand how serotonin receptors function at the single-cell level, what role different serotonin receptors play in regulating brain-wide activity and, in turn, human behavior, remains unknown. Here, we developed transcriptomic–neuroimaging
P. Salvan, Madalena S. Fonseca, A. Winkler, Antoine Beauchamp, J. Lerch, H. Johansen-Berg   +5 more
semanticscholar   +1 more source

Serotonin reuptake inhibitors and cardiovascular disease [PDF]

, 2005
Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R., Drake-Holland, A.J., Noble, M.   +2 more
core   +1 more source

Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]

, 2020
Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core   +1 more source