Results 21 to 30 of about 103,177 (262)

Serotonin receptors in depression: from A to B [version 1; referees: 3 approved]

F1000Research, 2017
The role of serotonin in major depressive disorder (MDD) is the focus of accumulating clinical and preclinical research. The results of these studies reflect the complexity of serotonin signaling through many receptors, in a large number of brain regions,
Katherine M. Nautiyal, René Hen
doaj   +1 more source

Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression

Frontiers in Behavioral Neuroscience, 2014
Decreased serotonergic activity has been implicated in anxiety and major depression, and antidepressants directly or indirectly increase the long-term activity of the serotonin system.
Paul R Albert, Faranak eVahid-Ansari, Faranak eVahid-Ansari, Christine eLuckhart, Christine eLuckhart   +4 more
doaj   +1 more source

Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice. [PDF]

PLoS ONE, 2009
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. However, the
Stéphane Doly, Jesus Bertran-Gonzalez, Jacques Callebert, Alexandra Bruneau, Sophie Marie Banas, Arnauld Belmer, Katia Boutourlinsky, Denis Hervé, Jean-Marie Launay, Luc Maroteaux   +9 more
doaj   +1 more source

Antidepressants in pregnancy: applying causal epidemiological methods to understand service-use outcomes in women and long-term neurodevelopmental outcomes in exposed children

Health Technology Assessment, 2023
Background Antidepressants are commonly prescribed during pregnancy, despite a lack of evidence from randomised trials on the benefits or risks.
Heuvelman Hein, Davies Neil M, Ben-Shlomo Yoav, Emond Alan, Evans Jonathan, Gunnell David, Liebling Rachel, Morris Richard, Payne Rupert, Storey Claire, Viner Maria, Rai Dheeraj   +11 more
doaj   +1 more source

Serotonin Receptors: Genetic insights into serotonin function [PDF]

Current Biology, 1995
Targeted disruption of the genes for the 5-HT1B and 5-HT2C serotonin receptors and monoamine oxidase A have confirmed pharmacological experiments and revealed unexpected behavioral roles for serotonin.
Heath, Mark J.S., Hen, René
openaire   +2 more sources

A characterization of the Manduca sexta serotonin receptors in the context of olfactory neuromodulation.

PLoS ONE, 2013
Neuromodulation, the alteration of individual neuron response properties, has dramatic consequences for neural network function and is a phenomenon observed across all brain regions and taxa.
Andrew M Dacks, Vincenzina Reale, Yeli Pi, Wujie Zhang, Joel B Dacks, Alan J Nighorn, Peter D Evans   +6 more
doaj   +1 more source

Glycogen Synthase Kinase-3 is an intermediate modulator of serotonin neurotransmission

Frontiers in Molecular Neuroscience, 2011
Serotonin is a neurotransmitter with broad functions in brain development, neuronal activity, and behaviors; and serotonin is the prominent drug target in several major neuropsychiatric diseases.
Xiaohua eLi, Abigail ePolter
doaj   +1 more source

Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease

Behavioural Neurology, 2021
There are nearly 50 million Alzheimer’s disease (AD) patients worldwide, 90% of whom develop behavioral and psychological symptoms of dementia (BPSD), which increase the mortality rate of patients, and impose an economic and care burden on families and ...
Hui-Hua Li, Xiao-Yan Yao, Sheng Tao, Xue Sun, Pan-pan Li, Xi-xin Li, Zhu-Li Liu, Chao Ren   +7 more
doaj   +1 more source

Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor. [PDF]

PLoS ONE, 2017
Tetrahydroprotoberberines (THPBs) are isoquinoline alkaloids isolated from the Chinese herb Corydalis yanhusuo. In the present study, we performed competitive binding assays to examine the binding of l-THBr to neurotransmitter receptors known to be ...
Guiyun Mi, Shuai Liu, Jian Zhang, Huichun Liang, Yunyun Gao, Nuomin Li, Boyang Yu, Hongju Yang, Zheng Yang   +8 more
doaj   +1 more source

Effects of Electron Radiation on Serotonin Signaling and Reactivity of Rat Gastric Smooth Muscle

Toxics, 2023
Ionizing radiation in radiotherapy can disrupt cellular functions based on radiation type, energy, and dose. However, investigations on the effects of accelerated electrons, particularly on serotonin mediation, are limited.
Raina Ardasheva, Natalia Prissadova, Valentin Turiyski, Anna Tolekova, Athanas Krastev, Mina Pencheva, Veselin Popov   +6 more
doaj   +1 more source