Results 81 to 90 of about 709,109 (292)

MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS

Фундаментальная и клиническая медицина, 2018
Aim. To investigate the effects of serotonin on duodenal motor activity. Materials and Methods. Experiments were performed on Wistar rats (n=83) which received nembutal anesthesia.
VIKTOR M. Smirnov, DMITRIY S. Sveshnikov, ANDREY V. Kuchuk, TATIANA E. Kuznetsova, ELENA D. Ignatova, LARISA V. Trubetskaya   +5 more
doaj  

Behavioral Mechanisms That Depend on Dopamine and Serotonin in Interact With the Antipsychotics Risperidone and Aripiprazole

Journal of Experimental Neuroscience, 2018
The neurotransmitters dopamine and serotonin participate in specific behavioral neuromuscular mechanisms in the nematode Caenorhabditis elegans . Dopamine is involved in the gentle touch response and serotonin in the pharyngeal pumping rate.
Jaime Osuna-Luque, Ángel Rodríguez-Ramos, María del Mar Gámez-del-Estal, Manuel Ruiz-Rubio   +3 more
doaj   +1 more source

Flexible IGZO Field‐Effect Transistor Biosensor Platform for Mechanically Stable and Cortisol Detection

Advanced Electronic Materials, EarlyView.
A flexible indium–gallium–zinc oxide field‐effect transistor platform on polyimide is developed for electrostatic cortisol detection. Wafer‐scale fabricated devices exhibit uniform electrical characteristics and maintain stable operation under mechanical bending.
Ngoc Thanh Ho, Sina Jamali, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +3 more
wiley   +1 more source

In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug

Scientific Reports, 2018
PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-
Yanan Xu, Xiaoyin Zhu, Hongbo Wang, Shanyue Sun, Xin Yue, Jingwei Tian   +5 more
doaj   +1 more source

Serotonin modulates insect hemocyte phagocytosis via two different serotonin receptors

eLife, 2016
Serotonin (5-HT) modulates both neural and immune responses in vertebrates, but its role in insect immunity remains uncertain. We report that hemocytes in the caterpillar, Pieris rapae are able to synthesize 5-HT following activation by ...
Yi-xiang Qi, Jia Huang, Meng-qi Li, Ya-su Wu, Ren-ying Xia, Gong-yin Ye   +5 more
doaj   +1 more source

Deconstructing antiobesity compound action : requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects

, 2010
The now-banned anorectic molecule, dexfenfluramine, promotes serotonin release through a serotonin transporter-dependent mechanism, and it has been widely prescribed for the treatment of obesity.
Silvina L Diaz, Boutourlinsky, Katia, Luc Maroteaux, Diaz, Silvina L., Corinne Collet, Jean-Marie Launay, Banas, Sophie,, Banas, Sophie M., Belmer, Arnauld, Stéphane Doly, Launay, Jean-Marie, Jacques Callebert, Collet, Corinne, Diaz, Silvina,, Banas, Sophie, M., Doly, Stephane, Sophie M Banas, Maroteaux, Luc, Callebert, Jacques, Arnauld Belmer, Katia Boutourlinsky, Diaz, Silvina, L.   +21 more
core   +1 more source

Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf, Andrea Accogli, Fadi F. Hamdan, Francesca Nardecchia, Toshiyuki Itai, Kenneth A. Myers, Christine Saint Martin, Myriam Srour   +7 more
wiley   +1 more source

The importance of serotonin in the gastrointestinal tract

Journal of Education, Health and Sport, 2017
Introduction. Serotonin also called as 5-hydroxytryptamine (5-HT) is a very important neurotransmitter in the central nervous system, also plays an important role in the gastrointestinal tract.
Jarosław Koza, Renata Kwiatkowska, Adam Jurgoński, Małgorzata Pujanek, Monika Ameryk, Piotr Sikorski, Agnieszka Meder, Maciej Świątkowski   +7 more
doaj   +3 more sources

Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain

Molecular Pain, 2018
Vortioxetine is a multimodal antidepressant that potently antagonizes 5-HT3 serotonin receptors, inhibits the high-affinity serotonin transporter, activates 5-HT1A and 5-HT1B receptors, and antagonizes 5-HT1D and 5-HT7 receptors.
Anna Rita Zuena, Daniela Maftei, Giovanni Sebastiano Alemà, Francesca Dal Moro, Roberta Lattanzi, Paola Casolini, Ferdinando Nicoletti   +6 more
doaj   +1 more source

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source