Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Evaluation of [C-11]SA5845 and [C-11]SA4503 for imaging of sigma receptors in tumors by animal PET [PDF]
, 2005 Sigma receptors are expressed in a wide variety of tumor cell lines, and are expressed in proliferating cells. A radioligand for the visualization of sigma receptors could be useful for selective detection of primary tumors and their metastases, and for ...
Kubota, K +6 more
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Neuroleptic binding to sigma receptors: possible involvement in neuroleptic-induced acute dystonia [PDF]
, 1997 Several antipsychotic drugs, belonging to various chemical classes, were compared for their affinity for the sigma, dopamine-D2, and muscarinic receptors.
Maloteaux, Jean-Marie +5 more
core +1 more source
Pharmacological Effects of .SIGMA.-Receptor Ligands. Sigma (.SIGMA.) receptor and neurosteroids.
Folia Pharmacologica Japonica, 1999 UEDA, Hiroshi, YOSHIDA, Akira
openaire +3 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Synthesis of a drug discovery library for the identification of sigma receptors modulators [PDF]
, 2017 Synthesis of a drug discovery library for the identification of sigma receptors ...
Daniela Rossi +14 more
core +1 more source
Psychedelics and immunomodulation: Novel approaches and therapeutic opportunities
Frontiers in Immunology, 2015 Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant modulatory effects on immune responses by altering signaling pathways involved in inflammation, cellular ...
Attila eSzabo
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Sigma-1 Receptor Imaging in the Brain:Cerebral sigma-1 receptors and cognition: Small-animal PET studies using 11C-SA4503 [PDF]
, 2014 The sigma-1 receptor is a unique orphan receptor, strongly expressed in neurons and glia. Sigma-1 receptors are involved in several central nervous system (CNS) disorders like depression, anxiety, psychosis, schizophrenia, Parkinson’s disease, Alzheimer ...
Kuzhuppilly Ramakrishnan, Nisha
core