Results 1 to 10 of about 1,199,024 (153)

Sigma-1 receptor and seizures

Pharmacological Research, 2023
Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities.
Edijs Vavers, Liga Zvejniece, Maija Dambrova   +2 more
doaj   +2 more sources

Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication

Journal of Pharmacological Sciences, 2015
Endoplasmic reticulum (ER) protein sigma-1 receptor represents unique chaperone activity in the central nervous system, and it exerts a potent influence on a number of neurotransmitter systems. Several lines of evidence suggest that activation of sigma-1
Kenji Hashimoto
doaj   +3 more sources

Hazards of Using Masking Protocols When Performing Ligand Binding Assays: Lessons From the Sigma-1 and Sigma-2 Receptors

Frontiers in Pharmacology, 2020
Sigma-1 and sigma-2 receptors are emerging therapeutic targets. Although the molecular identity of the sigma-2 receptor has recently been determined, receptor quantitation has used, and continues to use, the sigma-1 selective agents (+) pentazocine or ...
Haider Abbas, Haider Abbas, Preeti Borde, Gary B. Willars, David R. Ferry, Stephen T. Safrany   +5 more
doaj   +1 more source

The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

Molecular Brain, 2020
The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain.
Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos, Javier Garzón-Niño   +4 more
doaj   +1 more source

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells

Pathogens, 2021
(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern.
David A. Ostrov, Andrew P. Bluhm, Danmeng Li, Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam, Kalpana K. Bhanumathy, Jocelyne Lew, Darryl Falzarano, Franco J. Vizeacoumar, Joyce A. Wilson, Marco Mottinelli, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R. McCurdy, Michael H. Norris   +15 more
doaj   +1 more source

Negative Impact of Sigma-1 Receptor Agonist Treatment on Tissue Integrity and Motor Function Following Spinal Cord Injury

Frontiers in Pharmacology, 2021
In traumatic spinal cord injury, the initial trauma is followed by a cascade of impairments, including excitotoxicity and calcium overload, which ultimately induces secondary damages. The sigma-1 receptor is widely expressed in the central nervous system
Alise Lattard, Gaëtan Poulen, Gaëtan Poulen, Sylvain Bartolami, Yannick N. Gerber, Florence E. Perrin, Florence E. Perrin   +6 more
doaj   +1 more source

Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.

PLoS ONE, 2012
(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors.
Xiao-Fei Gao, Jin-Jing Yao, Yan-Lin He, Changlong Hu, Yan-Ai Mei   +4 more
doaj   +1 more source

Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review

International Journal of Cardiology: Heart & Vasculature, 2020
Sigma-1 receptors are ligand-regulated chaperone proteins, involved in several cellular mechanisms. The aim of this systematic review was to examine the effects that the sigma-1 receptor has on the cardiovascular system.
Rebecca Lewis, Jiaqi Li, Peter J McCormick, Christopher L-H Huang, Kamalan Jeevaratnam   +4 more
doaj   +1 more source

Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury

Scientific Reports, 2023
Sigma-1 Receptor has been shown to localize to sites of peripheral nerve injury and back pain. Radioligand probes have been developed to localize Sigma-1 Receptor and thus image pain source.
Ethan Schonfeld, Thomas Michael Johnstone, Ghani Haider, Aaryan Shah, Neelan Joseph Marianayagam, Sandip Biswal, Anand Veeravagu   +6 more
doaj   +1 more source

Defining the ligand-dependent proximatome of the sigma 1 receptor

Frontiers in Cell and Developmental Biology, 2023
Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerative diseases to cancer and COVID-19. S1R is ubiquitously expressed throughout the visceral organs, nervous, immune and cardiovascular
Jing Zhao, Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Barbara A. Mysona, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Yutao Liu, Sylvia B. Smith, Sylvia B. Smith, Sylvia B. Smith, Graydon B. Gonsalvez, Kathryn E. Bollinger, Kathryn E. Bollinger, Kathryn E. Bollinger   +16 more
doaj   +1 more source