Results 21 to 30 of about 801,740 (256)

The cholinergic system, sigma-1 receptors and cognition [PDF]

Behavioural Brain Research, 2011
This article provides an overview of present knowledge regarding the relationship between the cholinergic system and sigma-1 receptors, and discusses potential applications of sigma-1 receptor agonists in the treatment of memory deficits and cognitive disorders.
Aren, van Waarde, Nisha K, Ramakrishnan, Anna A, Rybczynska, Philip H, Elsinga, Kiichi, Ishiwata, Ingrid M, Nijholt, Paul G M, Luiten, Rudi A, Dierckx   +7 more
openaire   +2 more sources

Defining the ligand-dependent proximatome of the sigma 1 receptor

Frontiers in Cell and Developmental Biology, 2023
Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerative diseases to cancer and COVID-19. S1R is ubiquitously expressed throughout the visceral organs, nervous, immune and cardiovascular
Jing Zhao, Jing Zhao, Rajalakshmi Veeranan-Karmegam, Frederick C. Baker, Barbara A. Mysona, Barbara A. Mysona, Barbara A. Mysona, Pritha Bagchi, Yutao Liu, Yutao Liu, Sylvia B. Smith, Sylvia B. Smith, Sylvia B. Smith, Graydon B. Gonsalvez, Kathryn E. Bollinger, Kathryn E. Bollinger, Kathryn E. Bollinger   +16 more
doaj   +1 more source

Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel

Frontiers in Pharmacology, 2017
The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes.
Kang Zhang, Zhe Zhao, Liting Lan, Xiaoli Wei, Liyun Wang, Xiaoyan Liu, Haitao Yan, Jianquan Zheng   +7 more
doaj   +1 more source

A Review of the Human Sigma-1 Receptor Structure [PDF]

, 2017
The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential.
Ossa, F, Schnell, J, Ortega-Roldan, J
openaire   +3 more sources

Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection [PDF]

, 2017
Sigma-1 receptors are molecular chaperones that may act as pathological mediators and targets for novel therapeutic applications in neurodegenerative diseases. Accumulating evidence indicates that sigma-1 ligands can either directly or indirectly modulate multiple neurodegenerative processes, including excitotoxicity, calcium dysregulation ...
Linda, Nguyen, Brandon P, Lucke-Wold, Shona, Mookerjee, Nidhi, Kaushal, Rae R, Matsumoto   +4 more
openaire   +2 more sources

Crucial Interactions Between Selective Serotonin Uptake Inhibitors and Sigma-1 Receptor in Heart Failure

Journal of Pharmacological Sciences, 2013
Depression is associated with a substantial increase in the risk of developing heart failure and is independently associated with increased cardiovascular morbidity and mortality. Inversely, cardiovascular disease can lead to severe depression.
Md. Shenuarin Bhuiyan, Hideaki Tagashira, Kohji Fukunaga   +2 more
doaj   +1 more source

Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites

Contact, 2021
Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication ...
Vladimir Zhemkov, Jen Liou, Ilya Bezprozvanny   +2 more
doaj   +1 more source

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Neurobiology of Disease, 2019
Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein with a polyglutamine expansion.
Chelsy R. Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R. Hayden, Christopher A. Ross   +5 more
doaj   +1 more source

Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways.

PLoS ONE, 2008
BackgroundSelective serotonin reuptake inhibitors (SSRIs) have been widely used and are a major therapeutic advance in psychopharmacology. However, their pharmacology is quite heterogeneous.
Tomoko Nishimura, Tamaki Ishima, Masaomi Iyo, Kenji Hashimoto   +3 more
doaj   +1 more source

The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson’s Disease (PD) and Major Depressive Disorder (MDD)

Frontiers in Pharmacology, 2019
Sigma receptors, including Sigma-1 receptors and Sigma-2 receptors, are highly expressed in the CNS. They are intracellular chaperone proteins. Sigma-1 receptors localize mainly at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM ...
Kai Yang, Changcai Wang, Taolei Sun, Taolei Sun   +3 more
doaj   +1 more source