Pharmacological and Pathological Implications of Sigma-1 Receptor in Neurodegenerative Diseases [PDF]
BiomedicinesOriginally identified as a potential receptor for opioids, the sigma-1 receptor is now recognized as an intracellular chaperone protein associated with mitochondria-associated membranes at the endoplasmic reticulum (ER).
Noah Drewes +3 more
doaj +2 more sources
Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs
Journal of Pharmacological Sciences, 2015 Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer.
Teruo Hayashi
doaj +3 more sources
The sigma-1 receptor as a neurohomeostatic decision hub for GABARAP-mediated receptor trafficking and macroautophagy [PDF]
Frontiers in Molecular BiosciencesGamma-aminobutyric acid receptor-associated protein (GABARAP) is a multifunctional member of the autophagy-related (ATG8) protein family, playing key roles in two distinct cellular pathways: macroautophagy and plasma membrane protein trafficking.
Marius Wilhelm Baeken +4 more
doaj +2 more sources
Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. [PDF]
, 2014 The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory ...
Frecska, Ede +3 more
core +22 more sources
Viewpoints Sigma-1 receptor agonist fluvoxamine for multiple sclerosis [PDF]
Brain, Behavior, & Immunity - HealthAccumulating evidence suggests that the Epstein-Barr virus (EBV) plays a key role in the development of multiple sclerosis (MS). Additionally, depressive symptoms often precede the onset of MS.
Kenji Hashimoto
doaj +2 more sources
TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death [PDF]
, 2019 Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97).
Hawkins, William G. +9 more
core +3 more sources
3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (σ1) receptor [PDF]
, 2013 Pentacycloundecylamine (PCU) derived compounds have been shown to be promising lead structures for the development of novel drug candidates aimed at a variety of neurodegenerative and psychiatric diseases.
Ablordeppey +31 more
core +1 more source
Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel
Frontiers in Pharmacology, 2017 The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes.
Kang Zhang +7 more
doaj +1 more source
Molecules, 2020 The sigma receptors were classified into sigma-1 and sigma-2 receptor based on their different pharmacological profiles. In the past two decades, our understanding of the biological and pharmacological properties of the sigma-1 receptor is increasing ...
Kai Yang +5 more
doaj +1 more source
Rapid reduction of sigma(1)-Receptor binding and F-18-FDG uptake in rat gliomas after in vivo treatment with doxorubicin [PDF]
, 2007 sigma-Receptors are strongly overexpressed in most rodent and human tumors and are proliferation markers. To evaluate the potential of a radiolabeled sigma(1)-ligand for therapy monitoring, we compared early changes of C-11-1-(3,4-dimethoxyphenethyl)-4 ...
de Jong, Johan R. +5 more
core +1 more source