Results 1 to 10 of about 821,392 (140)

Sigma-1-targeting multimodal compound HBK-15 reverses memory deficits and restores hippocampal plasticity under NMDA hypofunction [PDF]

Neurotherapeutics
Memory impairment is among the most disabling features of depression and schizophrenia, yet remains largely untreated by available pharmacotherapies.
Kinga Sałaciak, Klaudia Lustyk, Angelika Jagielska, Małgorzata Szafarz, Sara Inteiro-Oliveira, Maria José Diógenes, Sara Xapelli, Paulina Schnur, Lucy Morton, Erin Moran, Jacques Ferreira, Shuzo Sakata, Lucie Crouzier, Johann Meunier, Benjamin Delprat, Tangui Maurice, Karolina Pytka   +16 more
doaj   +2 more sources

Advancing depression treatment: the role of sigma receptor ligands [PDF]

Frontiers in Neuroscience
Depression, one of the most prevalent neuropsychiatric disorders, continues to pose escalating global health challenges. Despite the discovery of numerous antidepressants, their clinical applications are limited, and there is still an urgent need to ...
Peng Zhang, Peng Zhang, Zeqiong Ning, Haixia Chen, Jia Chen, Zhihong Lu, Feifei Xu   +6 more
doaj   +2 more sources

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

Pharmaceuticals, 2023
Itch and pain are closely related but distinct sensations that share largely overlapping mediators and receptors. We hypothesized that the novel, multi-target compound E153 has the potential to attenuate pain and pruritus of different origins.
Szczepan Mogilski, Monika Kubacka, Artur Świerczek, Elżbieta Wyska, Katarzyna Szczepańska, Jacek Sapa, Katarzyna Kieć-Kononowicz, Dorota Łażewska   +7 more
doaj   +1 more source

Hazards of Using Masking Protocols When Performing Ligand Binding Assays: Lessons From the Sigma-1 and Sigma-2 Receptors

Frontiers in Pharmacology, 2020
Sigma-1 and sigma-2 receptors are emerging therapeutic targets. Although the molecular identity of the sigma-2 receptor has recently been determined, receptor quantitation has used, and continues to use, the sigma-1 selective agents (+) pentazocine or ...
Haider Abbas, Haider Abbas, Preeti Borde, Gary B. Willars, David R. Ferry, Stephen T. Safrany   +5 more
doaj   +1 more source

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells

Pathogens, 2021
(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern.
David A. Ostrov, Andrew P. Bluhm, Danmeng Li, Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam, Kalpana K. Bhanumathy, Jocelyne Lew, Darryl Falzarano, Franco J. Vizeacoumar, Joyce A. Wilson, Marco Mottinelli, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R. McCurdy, Michael H. Norris   +15 more
doaj   +1 more source

Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Memantine is an approved drug for the treatment of Alzheimer’s disease (AD). Autophagy, lysosome dysfunction, and sigma receptors have possible roles in the pathophysiology of AD.
Mojtaba Keshavarz, Majid Reza Farrokhi, Elahe Amirinezhad Fard, Mohammad Mehdipour   +3 more
doaj   +1 more source

Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review

International Journal of Cardiology: Heart & Vasculature, 2020
Sigma-1 receptors are ligand-regulated chaperone proteins, involved in several cellular mechanisms. The aim of this systematic review was to examine the effects that the sigma-1 receptor has on the cardiovascular system.
Rebecca Lewis, Jiaqi Li, Peter J McCormick, Christopher L-H Huang, Kamalan Jeevaratnam   +4 more
doaj   +1 more source

Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development

Frontiers in Pharmacology, 2022
Depression is the most common type of neuropsychiatric illness and has increasingly become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 has dramatically increased the incidence of depression and has significantly ...
Peng Ren, Jingya Wang, Nanxi Li, Guangxiang Li, Hui Ma, Yongqi Zhao, Yunfeng Li, Yunfeng Li   +7 more
doaj   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen, Dehghani, Faramarz, Ehrlich, Angela, Geisslinger, Gerd, Hobusch, Constance, Kallendrusch, Sonja, Koch, Marco, Nowicki, Marcin, Ziebell, Simone   +8 more
core   +9 more sources

The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson’s Disease (PD) and Major Depressive Disorder (MDD)

Frontiers in Pharmacology, 2019
Sigma receptors, including Sigma-1 receptors and Sigma-2 receptors, are highly expressed in the CNS. They are intracellular chaperone proteins. Sigma-1 receptors localize mainly at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM ...
Kai Yang, Changcai Wang, Taolei Sun, Taolei Sun   +3 more
doaj   +1 more source