Results 31 to 40 of about 530,601 (300)

Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs

Journal of Pharmacological Sciences, 2015
Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer.
Teruo Hayashi
doaj   +1 more source

A Structure- and Ligand-Based Virtual Screening of a Database of “Small” Marine Natural Products for the Identification of “Blue” Sigma-2 Receptor Ligands

Marine Drugs, 2018
Sigma receptors are a fascinating receptor protein class whose ligands are actually under clinical evaluation for the modulation of opioid analgesia and their use as positron emission tomography radiotracers.
Giuseppe Floresta, Emanuele Amata, Carla Barbaraci, Davide Gentile, Rita Turnaturi, Agostino Marrazzo, Antonio Rescifina   +6 more
doaj   +1 more source

The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders

Research Results in Pharmacology, 2023
Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear.
Sakeena P. Bairamova, Dmitry S. Petelin, Roman V. Akhapkin, Nikita V. Kudryashov, Olga Yu. Sorokina, Sergey A. Semin, Veronika Panfilova, Beatrice A. Volel   +7 more
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The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0 [PDF]

, 2023
: For some time now, the research on sigma receptors has been at a high level of maturity but, despite everything that has already been achieved, further work in this field still holds huge appeal, with vast possibilities for original discoveries [...]
Abate, Carmen, Tangui Maurice, Carmen Abate, Maurice, Tangui   +3 more
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PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships

Frontiers in Pharmacology, 2020
These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting with ...
Carmen Abate, Mauro Niso, Francesca Serena Abatematteo, Marialessandra Contino, Nicola Antonio Colabufo, Francesco Berardi   +5 more
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Sigma-2 Receptor—A Potential Target for Cancer/Alzheimer’s Disease Treatment via Its Regulation of Cholesterol Homeostasis

Molecules, 2020
The sigma receptors were classified into sigma-1 and sigma-2 receptor based on their different pharmacological profiles. In the past two decades, our understanding of the biological and pharmacological properties of the sigma-1 receptor is increasing ...
Kai Yang, Cheng Zeng, Changcai Wang, Meng Sun, Dan Yin, Taolei Sun   +5 more
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Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca2+ homeostasis in cardiomyocytes

Journal of Pharmacological Sciences, 2023
The Sigma-1 receptor (Sigmar1) is downregulated in heart failure model mice with mitochondrial dysfunction. However, the mechanism in detail has not been investigated.
Hideaki Tagashira, Md. Shenuarin Bhuiyan, Yasuharu Shinoda, Ichiro Kawahata, Tomohiro Numata, Kohji Fukunaga   +5 more
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Role of germinant receptors in Caco-2 cell-initiated germination of Bacillus cereus ATCC 14579 endospores [PDF]

, 2009
Spores obtained from Bacillus cereus ATCC 14579 and mutant strains lacking each of seven germinant receptor operons were exposed to differentiated Caco-2 cells and monitored for germination.
Wijnands, L.M., Abee, T., Hornstra, L.M., Roubos-van den Hil, P.J., Voort, M., van der, van der Voort, M.   +5 more
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The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum

Frontiers in Pharmacology, 2017
Drug addiction is a chronic, debilitating disease that affects millions of people around the world causing a substantial societal burden. Despite decades of research efforts, treatment possibilities remain limited and relapse represents the most ...
Anna M. Klawonn, Anna Nilsson, Carl F. Rådberg, Sarah H. Lindström, Mia Ericson, Björn Granseth, David Engblom, Michael Fritz   +7 more
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The cholinergic system, sigma-1 receptors and cognition [PDF]

, 2011
This article provides an overview of present knowledge regarding the relationship between the cholinergic system and sigma-1 receptors, and discusses potential applications of sigma-1 receptor agonists in the treatment of memory deficits and cognitive ...
Ishiwata, Kiichi,, Van Waarde, Aren, Rybczynska, Anna A.,, Elsinga, Philip H.,, Dierckx, Rudi, Elsinga, Philip H, Elsinga, Philip H., Luiten, Paul GM, van Waarde, Aren; id_orcid, Waarde, Aren van,, Ishiwata, Kiichi, Dierckx, Rudi A.,, Luiten, Paul G. M., Ramakrishnan, Nisha K.,, Ramakrishnan, Nisha K., Nijholt, Ingrid M.,, Rybczynska, Anna A, Rybczynska, Anna A., Nijholt, Ingrid M, Nijholt, Ingrid M., Luiten, Paul G.M.,, Dierckx, Rudi A., Ramakrishnan, Nisha K   +22 more
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