Results 31 to 40 of about 821,561 (307)
STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
Cardiac Sigma Receptors – An Update
Physiological Research, 2018 More than four decades passed since sigma receptors were first mentioned. Since then, existence of at least two receptor subtypes and their tissue distributions have been proposed. Nowadays, it is clear, that sigma receptors are unique ubiquitous proteins with pluripotent function, which can interact with so many different classes of proteins.
T, Stracina, M, Novakova
openaire +2 more sources
Pregnancy reduces brain sigma receptor function [PDF]
British Journal of Pharmacology, 1999 Sigma (σ) receptors have recently been cloned, though their endogenous ligand(s) remain unidentified. However, some neuroactive steroids, such as progesterone, have a high affinity for these receptors. Some σ ligands, such as DTG, (+)‐pentazocine and DHEA, act as σ ‘agonists’ by potentiating the neuronal response to NMDA. Others, such as haloperidol,
R, Bergeron, C, de Montigny, G, Debonnel
openaire +2 more sources
Molecules, 2020 The sigma receptors were classified into sigma-1 and sigma-2 receptor based on their different pharmacological profiles. In the past two decades, our understanding of the biological and pharmacological properties of the sigma-1 receptor is increasing ...
Kai Yang +5 more
doaj +1 more source
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. [PDF]
, 2008 Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids; however, these responses come at the cost of potential autoimmunity owing to inappropriate recognition of self nucleic acids.
Barton, Gregory M +6 more
core +2 more sources
Journal of Pharmacological Sciences, 2023 The Sigma-1 receptor (Sigmar1) is downregulated in heart failure model mice with mitochondrial dysfunction. However, the mechanism in detail has not been investigated.
Hideaki Tagashira +5 more
doaj +1 more source
Frontiers in Pharmacology, 2017 Drug addiction is a chronic, debilitating disease that affects millions of people around the world causing a substantial societal burden. Despite decades of research efforts, treatment possibilities remain limited and relapse represents the most ...
Anna M. Klawonn +7 more
doaj +1 more source
Effect of SA 4503 on the locomotor stimulatory and discriminative stimulus properties of psychostimulants [PDF]
Title from PDF of title page (University of Missouri--Columbia, viewed on October 25, 2010).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the ...
Rodvelt, Kelli Renee, 1981-
core +1 more source
Molecular Imaging, 2011 We synthesized and characterized two novel fluorescent sigma-2 receptor selective ligands, SW120 and SW116, and evaluated these ligands as potential probes for imaging cell proliferation.
Chenbo Zeng +9 more
doaj +1 more source
Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
PLoS ONE, 2012 (+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors.
Xiao-Fei Gao +4 more
doaj +1 more source