Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development
Frontiers in Pharmacology, 2022 Depression is the most common type of neuropsychiatric illness and has increasingly become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 has dramatically increased the incidence of depression and has significantly ...
Peng Ren +7 more
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The expression and functional characterization of sigma (sigma) 1 receptors in breast cancer cell lines [PDF]
, 2006 Sigma (σ) receptors have been implicated in cancer. However, to date there is little molecular data demonstrating the role of σ1 receptors in cancer. Expression of σ1 receptors in various human cancer cell lines in comparison to non-cancerous cell lines ...
Uysal Onganer, P. +4 more
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Targeting Sigma-1 and Sigma-2 Receptors in Neuropathic Pain: Pharmacology, Ligand Development, and Translational Progress. [PDF]
Brain SciBackground: Neuropathic pain remains a major unmet clinical challenge. Growing evidence identifies sigma receptors (σRs) as pivotal intracellular modulators of maladaptive stress signaling, positioning them as promising non-opioid targets for chronic ...
Reale C +3 more
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Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders [PDF]
, 2017 Accumulating evidence suggests that sigma-1 receptors play a role in the pathophysiology of neuropsychiatric diseases, as well as in the mechanisms of some selective serotonin reuptake inhibitors (SSRIs).
Yakup Albayrak +3 more
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Hazards of using masking protocols when performing ligand binding assays: lessons from the sigma-1 and sigma-2 receptors. [PDF]
, 2021 Sigma-1 and sigma-2 receptors are emerging therapeutic targets. Although the molecular identity of the sigma-2 receptor has recently been determined, receptor quantitation has used, and continues to use, the sigma-1 selective agents (+) pentazocine or ...
David R. Ferry (8567838) +4 more
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Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel
Frontiers in Pharmacology, 2017 The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes.
Kang Zhang +7 more
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Biomedicines, 2021 Sigma (σ) receptors have attracted great interest since they are implicated in various cellular functions and biological processes and diseases, including various types of cancer. The receptor family consists of two subtypes: sigma-1 (σ1) and sigma-2 (σ2)
Evangelia Sereti +4 more
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Novel sigmaB regulation modules of Gram-positive bacteria involve the use of complex hybrid histidine kinases. [PDF]
, 2011 Contains fulltext : 97170.pdf (Publisher’s version ) (Closed access)A common bacterial strategy to cope with stressful conditions is the activation of alternative sigma factors that control specific regulons enabling targeted responses.
Christof Francke +9 more
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Cell Reports, 2019 Summary: Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from the
Eugen Brailoiu +8 more
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Adamantane-derived scaffolds targeting the sigma-2 receptor; an in vitro and in silico study
Saudi Pharmaceutical Journal, 2021 Novel adamantane-based compounds were synthesized and assessed as potential sigma-2 receptor ligands. Molecular docking and 50 ns molecular dynamic simulation were carried out to determine the binding modes, mechanism of interaction, and stability of ...
Mohammed A. Alamri, Mubarak A. Alamri
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