Cell Reports, 2019 Summary: Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from the
Eugen Brailoiu +8 more
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Adamantane-derived scaffolds targeting the sigma-2 receptor; an in vitro and in silico study
Saudi Pharmaceutical Journal, 2021 Novel adamantane-based compounds were synthesized and assessed as potential sigma-2 receptor ligands. Molecular docking and 50 ns molecular dynamic simulation were carried out to determine the binding modes, mechanism of interaction, and stability of ...
Mohammed A. Alamri, Mubarak A. Alamri
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Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
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Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs
Journal of Pharmacological Sciences, 2015 Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer.
Teruo Hayashi
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Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
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Marine Drugs, 2018 Sigma receptors are a fascinating receptor protein class whose ligands are actually under clinical evaluation for the modulation of opioid analgesia and their use as positron emission tomography radiotracers.
Giuseppe Floresta +6 more
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The Role of Sigma Receptors in Depression
Journal of Pharmacological Sciences, 2005 Behavioral models used to test potential antidepressants have shown that ligands that bind to sigma receptors possess “antidepressant-like” properties.
Jordanna E. Bermack, Guy Debonnel
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The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders
Research Results in Pharmacology, 2023 Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear.
Sakeena P. Bairamova +7 more
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Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin [PDF]
, 2012 Bradykinin-related peptides, universal mediators of inflammation collectively referred to as the kinins, are often produced in excessive amounts during microbial infections.
Alexander Faussner +16 more
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Frontiers in Pharmacology, 2020 These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting with ...
Carmen Abate +5 more
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