Results 41 to 50 of about 530,601 (300)
Sigma-1-targeting multimodal compound HBK-15 reverses memory deficits and restores hippocampal plasticity under NMDA hypofunction. [PDF]
NeurotherapeuticsMemory impairment is among the most disabling features of depression and schizophrenia, yet remains largely untreated by available pharmacotherapies.
Sałaciak K +16 more
europepmc +2 more sources
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY [PDF]
, 2021 The sigma-1 (σ1) receptor plays a significant role in many physiological functions and pathological disease states, and, as such, it represents an attractive therapeutic target for both agonists and antagonists.
Antonio LAGHEZZA +10 more
core
Molecular Imaging, 2011 We synthesized and characterized two novel fluorescent sigma-2 receptor selective ligands, SW120 and SW116, and evaluated these ligands as potential probes for imaging cell proliferation.
Chenbo Zeng +9 more
doaj +1 more source
Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
PLoS ONE, 2012 (+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors.
Xiao-Fei Gao +4 more
doaj +1 more source
Sigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis [PDF]
, 2023 Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or heme and also several unrelated xenobiotics/chemicals. They reside in the plasma membrane and in the membranes of the endoplasmic reticulum, mitochondria, and ...
Yangzom D. Bhutia +6 more
core +1 more source
A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa. [PDF]
PLoS Pathogens, 2009 Next to the two-component and quorum sensing systems, cell-surface signaling (CSS) has been recently identified as an important regulatory system in Pseudomonas aeruginosa.
María A Llamas +5 more
doaj +1 more source
Effect of sigma-1 receptor activation on corticosterone-induced mitochondrial damage in astrocytes
徐州医科大学学报Objective To investigate the protective effect and mechanism of sigma-1 receptors on corticosterone-induced mitochondrial damage in astrocytes. Methods A corticosterone-induced primary astrocyte damage model was established, and the sigma-1 receptor ...
TANG Weidong +3 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Sigma receptor ligands: novel applications in cancer imaging and treatment [PDF]
, 2012 Sigma receptoren (subtypes sigma-1 en sigma-2) zijn unieke bindingsplaatsen die een aanzienlijk hogere expressie vertonen in kanker dan in gezond weefsel.
Rybczynska, Anna A., +1 more
core
Pharmaceutical Fronts, 2021 A total of 20 novel aryl piperazine derivatives were designed and synthesized, and their structures were confirmed by mass spectrometry and nuclear magnetic resonance analyses. Their 5-HT1A and sigma-1 receptor affinities were determined, and six of them
Yan-Na Ni +7 more
doaj +1 more source