Results 41 to 50 of about 821,561 (307)
Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]
, 2010 Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S +16 more
core +1 more source
A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa. [PDF]
PLoS Pathogens, 2009 Next to the two-component and quorum sensing systems, cell-surface signaling (CSS) has been recently identified as an important regulatory system in Pseudomonas aeruginosa.
María A Llamas +5 more
doaj +1 more source
Expression in the human brain of retinoic acid induced 1, a protein associated with neurobehavioural disorders [PDF]
, 2014 Acknowledgements Funding was provided by the Wellcome Trust and Tenovus Scotland. Prof Fragoso is the recipient of a Post Doctoral Science without Borders grant from the Brazilian National Council for Scientific and Technological Development (CNPq, 37450/
Fragoso, Yara Dadalti +6 more
core +2 more sources
Role of sigma-1 receptors in neurodegenerative diseases
Journal of Pharmacological Sciences, 2015 Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial ...
Linda Nguyen +6 more
doaj +1 more source
Functional selectivity of GPCR-directed drug action through location bias. [PDF]
, 2017 G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco +6 more
core +3 more sources
Effect of sigma-1 receptor activation on corticosterone-induced mitochondrial damage in astrocytes
徐州医科大学学报Objective To investigate the protective effect and mechanism of sigma-1 receptors on corticosterone-induced mitochondrial damage in astrocytes. Methods A corticosterone-induced primary astrocyte damage model was established, and the sigma-1 receptor ...
TANG Weidong +3 more
doaj +1 more source
Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]
, 2018 The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A. +5 more
core +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Pharmaceutical Fronts, 2021 A total of 20 novel aryl piperazine derivatives were designed and synthesized, and their structures were confirmed by mass spectrometry and nuclear magnetic resonance analyses. Their 5-HT1A and sigma-1 receptor affinities were determined, and six of them
Yan-Na Ni +7 more
doaj +1 more source
The pharmacology of sigma-1 receptors [PDF]
Pharmacology & Therapeutics, 2009 Originally considered an enigmatic protein, the sigma-1 receptor has recently been identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum of cells. This discovery causes us to look back at the many proposed roles of this receptor, even before its molecular function was identified, in many diseases such as ...
Tangui, Maurice, Tsung-Ping, Su
openaire +2 more sources