Exploring Cheminformatic Toolsets for Predicting the Dermal Toxicity of Furanocoumarins [PDF]
, 2021 Linear furanocoumarins are skin sensitizers and anticancer agents whose appeal in skincare therapeutics is widely exploited. Owing to the need to predict the biological activities of medicines, this work aimed the investigate the predicted dermal ...
Couto, Rene Oliveira do +4 more
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Advances in Pharmacological and Pharmaceutical Sciences, 2023 Pharmacotherapy, in many cases, is practiced at a suboptimal level of performance in low- and middle-income countries (LMICs) although stupendous amounts of data are available regularly.
Muhammad Usman +5 more
doaj +1 more source
Macro- and Microscopic Study of the Effect of 2-Phenyl-3-Carbethoxy-4-Dimethylaminomethyl-5-Hydroxybenzofuran Hydrochloride (Vinboron) on the Gastrotoxicity of Ibuprofen in Experimental Rheumatoid Arthritis in Rats [PDF]
, 2017 Відомо, що окрім широкого спектру терапевтичних ефектів, нестероїдним протизапальним засобам притаманні такі побічних реакцій, як гастродуоденотоксичність, гепатотоксичність, кардіотоксичність, нефротоксичність, гематотоксичність, алергенність ...
Hladkykh, Fedir +2 more
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A brief overview of current drug repurposing approaches for COVID-19 management [PDF]
, 2020 This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares +1 more
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Мультимодальная анальгезия: полипрагмазия в обезболивании или рациональное применение нестероидных противовоспалительных средств для предотвращения хронизации боли [PDF]
, 2020 Pain is the psychophysiological reaction of an entire organism to a damaging factor. According to the literature, 30.0–75.0 % of patients suffer from severe pain in the postoperative period.
Hladkykh, Fedir
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Фармакопрофілактичні та фармакотерапевтичні підходи до послаблення пошкоджуючої дії іонізуючого опромінення: огляд інформаційних джерел [PDF]
, 2018 The purpose of the article is to synthesize the scientific points of view on modern approaches to pharmacological correction of radiation damage. Conducting medical treatment, aimed at eliminating the negative effects of exposure to ionizing radiation ...
Hladkykh, Fedir
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Chemoinformatic Approaches in the Study of Fluralaner and Afoxolaner-mediated Inhibition of l-glutamate-gated Chloride Channels [PDF]
, 2019 This work showcased the chemoinformatic study of isoxazoline ectoparasiticides: Fluralaner (FLU) and Afoxolaner (AFO) interactions with l-glutamate-gated chloride channels (3RHW).
Douglas Vieira Thomaz +2 more
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Investigation of Cyclobenzaprine Interactions with P450 Cytochromes CYP1A2 and CYP3A4 through Molecular Docking Tools [PDF]
, 2019 Cyclobenzaprine (CBP) is a centrally acting muscle relaxant whose myriad of therapeutic applications imply the need of better understanding its pharmacokinetics and thermodynamics.
Douglas Vieira Thomaz +3 more
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Predictive Modelling to Study the Electrochemical Behaviour of PdO, TiO2 and Perovskite-Type LaFeO3 Modified Carbon Paste Electrodes [PDF]
, 2019 Transition metals are highly sought after in electrode construction due to their eventual electrocatalytic effects. In this context, this work presents the study of several metal oxide modified electrodes focusing in the evaluation of their ...
Adelmo Menezes de Aguiar Filho +4 more
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Perisynaptic GABA Receptors: The Overzealous Protector
Advances in Pharmacological Sciences, 2012 An attempt to find pharmacological therapies to treat stroke patients and minimize the extent of cell death has seen the failure of dozens of clinical trials. As a result, stroke/cerebral ischemia is the leading cause of lasting adult disability.
Andrew N. Clarkson
doaj +1 more source