Results 11 to 20 of about 162,144 (130)

Rational Design for High Bioorthogonal Fluorogenicity of Tetrazine-Encoded Green Fluorescent Proteins. [PDF]

Nat Sci (Weinh), 2022
Targeted mutagenesis aided by ultrafast molecular spectroscopic insights into the tetrazine‐encoded green fluorescent proteins in action in physiologically relevant environments has effectively achieved the record‐high bioorthogonal fluorogenicity to date for next‐generation bioimaging and life science advances.
Tang L, Bednar RM, Rozanov ND, Hemshorn ML, Mehl RA, Fang C.   +5 more
europepmc   +2 more sources

Efficacy and Safety of a Polysaccharide-Based Natural Substance Complex in the Treatment of Obesity and Other Metabolic Syndrome Components: A Systematic Review

Frontiers in Drug Safety and Regulation, 2022
Introduction: Metabolic syndrome (MetS) is increasingly common in adults as well as in children and adolescents. However, preventing and treating MetS is one of the most pressing challenges for public health services worldwide.
Giuseppina Guarino, Felice Strollo, Peter Malfertheiner, Peter Malfertheiner, Teresa Della Corte, Teresa Della Corte, Stefano Stagi, Mario Masarone, Sandro Gentile, Sandro Gentile   +9 more
doaj   +1 more source

New regulation on medical devices made of substances: Opportunities and challenges for pharmacological and toxicological research

Frontiers in Drug Safety and Regulation, 2022
The Medical Device (MD) Regulation EU 2017/745 (MDR) has provided a completely new and more robust regulatory framework at guarantee of the safety and efficacy of therapeutic options accessing the market.
Carmela Fimognari, Enrique Barrajón-Catalán, Cristina Luceri, Eleonora Turrini, Emanuel Raschi, Elisabetta Bigagli   +5 more
doaj   +1 more source

Putting external validation performance of major bleeding risk models into context

Frontiers in Drug Safety and Regulation, 2022
When developing predictive models, model simplicity and performance often need to be balanced. We propose a novel methodology to put the performance of bleeding risk prediction models ORBIT, ATRIA, HAS-BLED, CHADS2, and CHA2DS2-VASc into perspective ...
Clair Blacketer, Clair Blacketer, Jenna M. Reps, Jenna M. Reps, Lu Wang, Patrick B. Ryan, Patrick B. Ryan, Zhong Yuan   +7 more
doaj   +1 more source

Deprescribing as a strategy for improving safety of medicines in older people: Clinical and regulatory perspective

Frontiers in Drug Safety and Regulation, 2022
The ageing process is associated with an increased probability of accumulating health deficits, chronic conditions and geriatric syndromes, leading to a growing prevalence of multimorbidity, defined as the co-occurrence of two or more chronic conditions (
Salvatore Crisafulli, Elisabetta Poluzzi, Carlotta Lunghi, Carlotta Lunghi, Vincenzo Di Francesco, Luca Pellizzari, Luca Pasina, Chiara Elli, Francesco Trotta, Agnese Cangini, Caterina Trevisan, Caterina Trevisan, Maria Beatrice Zazzara, Graziano Onder, Gianluca Trifirò   +14 more
doaj   +1 more source

Exploring opportunities for AI supported medication error categorization: A brief report in human machine collaboration

Frontiers in Drug Safety and Regulation, 2022
Understanding and mitigating medication errors is critical for ensuring patient safety and improving patient care. Correctly identifying medication errors in the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS ...
Allan Fong, Allan Fong, Christopher Bonk, Varvara Vasilchenko, Varvara Vasilchenko, Suranjan De, Douglas Kovich, Jo Wyeth   +7 more
doaj   +1 more source

Dual‐Mode Photovoltaic Bidirectional Inverter Operation for Seamless Power Transfer to DC and AC Loads with the Grid Interface

International Journal of Photoenergy, Volume 2019, Issue 1, 2019., 2019
This paper develops the photovoltaic bidirectional inverter (BI) operated in dual mode for the seamless power transfer to DC and AC loads. Normal photovoltaic (PV) output voltage is fed to boost converter, but in space application, boost converter is not so preferable. To overcome this, buck and boost converters are proposed in this paper.
M. Srikanth, B. Pakkiraiah, Poonam Upadhyay, S. Tara Kalyani, Jegadesan Subbiah   +4 more
wiley   +1 more source

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Frontiers in Pharmacology
The Vitamin D receptor (VDR) is a crucial nuclear receptor that plays a vital role in various physiological functions. To a larger extent, the genomic effects of VDR maintain general wellbeing, and its modulation holds implications for multiple diseases.
Minghe Yao, Minghe Yao, Patrick Kwabena Oduro, Ayomide M. Akintibu, Haifeng Yan   +4 more
doaj   +1 more source

UEG Week 2023 Moderated Posters

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 201-534, October 2023.
wiley   +1 more source

A global bibliometric and visualized analysis of the links between the autophagy and acute myeloid leukemia

Frontiers in Pharmacology
Background and objectives: Autophagy is a cellular process where damaged organelles or unwanted proteins are packaged into a double-membrane structure and transported to lysosomes for degradation.
Yao Gao, Zhenhui Wu, Zhenhui Wu, Yingfan Chen, Guangbin Shang, Yingjian Zeng, Yingjian Zeng, Yue Gao, Yue Gao   +8 more
doaj   +1 more source