Results 41 to 50 of about 162,144 (130)

Efficacy of combination therapy of vitamin D and bisphosphonates in the treatment of postmenopausal osteoporosis: a systematic review and meta-analysis

Frontiers in Pharmacology
ObjectiveThere is currently no consensus on whether the combination therapy of Vitamin D (VitD) and bisphosphonates offers superior efficacy compared to monotherapy in the treatment of postmenopausal osteoporosis.
Yuangui Yang, Mingyue Yang, Xuanyi Su, Feibin Xie   +3 more
doaj   +1 more source

Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

Molecular Therapy: Nucleic Acids
For cystic fibrosis patients, a lung-targeted gene therapy would significantly alleviate pulmonary complications associated with morbidity and mortality.
Melissa R. Soto, Mae M. Lewis, Jasmim Leal, Yuting Pan, Rashmi P. Mohanty, Arian Veyssi, Esther Y. Maier, Brittany J. Heiser, Debadyuti Ghosh   +8 more
doaj   +1 more source

Rescue of the endogenous FVIII expression in hemophilia A mice using CRISPR-Cas9 mRNA LNPs

Molecular Therapy: Nucleic Acids
Gene editing provides a promising alternative approach that may achieve long-term FVIII expression for hemophilia A (HemA) treatment. In this study, we investigated in vivo correction of a mutant factor VIII (FVIII) gene in HemA mice.
Chun-Yu Chen, Xiaohe Cai, Barbara A. Konkle, Carol H. Miao   +3 more
doaj   +1 more source

Embedding rehabilitation into cancer care continuum: an implementation study

Journal of Rehabilitation Medicine
Objectives: To implement and evaluate a rehabilitation-inclusive service delivery model at a tertiary cancer hospital. Methods: The “Rehab-Toolkit”, a structured assessment tool comprising validated functional measures, was introduced in an inpatient ...
Fary Khan, Bhasker Amatya, Alaeldin Elmalik, Krystal Song, Demi Diaz, Michael Dickinson   +5 more
doaj   +1 more source

product news

, 1982
Journal of Analytical Methods in Chemistry, Volume 4, Issue 4, Page 197-210, 1982.
wiley   +1 more source

Product News

, 1980
Journal of Analytical Methods in Chemistry, Volume 2, Issue 4, Page 226-230, 1980.
wiley   +1 more source

A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk

CPT: Pharmacometrics & Systems Pharmacology
Breastfeeding is the most complete nutritional method of feeding infants, but several impediments affect the decision to breastfeed, including questions of drug safety for medications needed during lactation.
Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami‐Hodjegan, Brian J. Schmidt, Lu Gaohua, Aleksandra Galetin   +7 more
doaj   +1 more source

Population PK modeling of certolizumab pegol in pregnant women with chronic inflammatory diseases

CPT: Pharmacometrics & Systems Pharmacology
Certolizumab pegol (CZP; CIMZIA™) is the only Fc‐free tumor necrosis factor inhibitor with data from a clinical study demonstrating no to minimal placental transfer. The pharmacokinetics (PK) of certolizumab pegol during pregnancy and postpartum in women
Denis Menshykau, Jagdev Sidhu, Laura Shaughnessy, Rocio Lledo‐Garcia, Pinky Dua, Marie Teil, Akash Khandelwal   +6 more
doaj   +1 more source

Physiologically based pharmacokinetic modeling of long‐acting extended‐release naltrexone in pregnant women with opioid use disorder

CPT: Pharmacometrics & Systems Pharmacology
Opioid use disorders (OUD) are a major issue in the U.S. Current treatments for pregnant women, like methadone and buprenorphine require daily dosing and have adverse effects.
Babajide Shenkoya, Mathangi Gopalakrishnan, Ahizechukwu C. Eke   +2 more
doaj   +1 more source

Machine learning models can predict cancer-associated disseminated intravascular coagulation in critically ill colorectal cancer patients

Frontiers in Pharmacology
BackgroundDue to its complex pathogenesis, the assessment of cancer-associated disseminated intravascular coagulation (DIC) is challenging. We aimed to develop a machine learning (ML) model to predict overt DIC in critically ill colorectal cancer (CRC ...
Li Qin, Li Qin, Jieling Mao, Jieling Mao, Min Gao, Min Gao, Jingwen Xie, Jingwen Xie, Zhikun Liang, Zhikun Liang, Xiaoyan Li, Xiaoyan Li   +11 more
doaj   +1 more source