Results 61 to 70 of about 162,144 (130)

Impact of camel milk lactoferrin peptides against breast cancer cells: in silico and in vitro study

Frontiers in Pharmacology
Background and AimsBreast cancer remains a significant global health concern, necessitating the exploration of novel therapeutic strategies. Despite advancements in cancer therapeutics, effective treatments with minimal side effects remain elusive ...
Othman Baothman, Othman Baothman, Ehab M. M. Ali, Ehab M. M. Ali, Hassan Alguridi, Salman Hosawi, Salman Hosawi, Emadeldin Hassan E. Konozy, Emadeldin Hassan E. Konozy, Isam M. Abu Zeid, Abrar Ahmad, Hisham N. Altayb, Hisham N. Altayb   +12 more
doaj   +1 more source

Identifying and overcoming challenges in the EMA’s qualification of novel methodologies: a two-year review

Frontiers in Pharmacology
The EMA Qualification of Novel Methodologies procedure qualifies methods, technologies and methodologies within a well-defined context of use in a pharma R&D context based on the evaluation of the presented scientific rationale and submitted data ...
Ana Drmić, Riccardo Saccà, Riccardo Saccà, Thorsten Vetter, Falk Ehmann   +4 more
doaj   +1 more source

Investigating the impact of a pharmacist intervention on inappropriate prescribing practices at hospital admission and discharge in older patients: a secondary outcome analysis from a randomized controlled trial

Therapeutic Advances in Drug Safety
Background: Inappropriate medication prescribing in older patients increases the risk of poorer health outcomes and increased costs. The IMMENSE trial, integrated a clinical pharmacist into the health care team, to improve medication therapy among older ...
Beate Hennie Garcia, Katharina Kaino Omma, Lars Småbrekke, Jeanette Schultz Johansen, Frode Skjold, Kjell Hermann Halvorsen   +5 more
doaj   +1 more source

The effectiveness and costs of intensive stroke rehabilitation and improvements in pa-tient pathway in Finland: a retrospective benchmarking controlled trial

Journal of Rehabilitation Medicine
Objective: To assess the effectiveness and costs of intensive stroke rehabilitation and improvements in patient pathway in the city of Lahti and in Päijät-Häme region compared with other parts in Finland.
Niko Korpi, Marja Mikkelsson, Unto Häkkinen, Antti Malmivaara   +3 more
doaj   +1 more source

Natural compounds in the fight against Staphylococcus aureus biofilms: a review of antibiofilm strategies

Frontiers in Pharmacology
Staphylococcus aureus is an important pathogen due to its ability to form strong biofilms and antibiotic resistance. Biofilms play an important role in bacterial survival against the host immune system and antibiotics.
Milad Kashi, Milad Noei, Zahra Chegini, Aref Shariati   +3 more
doaj   +1 more source

Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis. [PDF]

RNA Biol, 2022
Vos TJ, Kothe U.
europepmc   +1 more source

Celecoxib and rofecoxib have different effects on small intestinal ischemia/reperfusion injury in rats

Frontiers in Pharmacology
IntroductionIntestinal ischemia/reperfusion (I/R) injury is associated with high mortality and there is an unmet need for novel therapies. The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a ...
Szilvia B. László, Barbara Hutka, Barbara Hutka, András S. Tóth, András S. Tóth, Tamás Hegyes, Zsuzsanna O. Demeter, Zsuzsanna O. Demeter, Arezoo Haghighi, Arezoo Haghighi, Gerda Wachtl, Gerda Wachtl, Ágnes Kelemen, Anna Jakab, Klára Gyires, Klára Gyires, Zoltán S. Zádori, Zoltán S. Zádori   +17 more
doaj   +1 more source

Mass balance, metabolism, and pharmacokinetics of [14C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin’s lymphoma, in healthy Chinese volunteers

Frontiers in Pharmacology
IntroductionAmdizalisib (HMPL-689) is an ATP-competitive PI3Kδ inhibitor currently under investigation for treating Hodgkin’s lymphoma. This study aimed to evaluate the metabolism, excretion, pharmacokinetics, and safety profile of amdizalisib in healthy
Chun-Yang Zhao, Chun-Yang Zhao, Li-Jun Zhang, Li-Jun Zhang, Chan Sun, Chan Sun, Cheng-Yin Yu, Cheng-Yin Yu, Cheng-Yin Yu, Jian Wang, Yang Sai, Wei-Guo Su, Qian Chen, Qian Chen, Wei Wang, Wei Wang, Jing-Ying Jia, Jing-Ying Jia, Gang-Yi Liu, Gang-Yi Liu, Yan-Mei Liu, Yan-Mei Liu   +21 more
doaj   +1 more source

An ion mobility-mass spectrometry study of copper-metallothionein-2A: binding sites and stabilities of Cu-MT and mixed metal Cu-Ag and Cu-Cd complexes. [PDF]

Analyst, 2023
Fan L, Russell DH.
europepmc   +1 more source

High-density lipoprotein protects normotensive and hypertensive rats against ischemia-reperfusion injury through differential regulation of mTORC1 and mTORC2 signaling

Frontiers in Pharmacology
BackgroundHigh-density lipoprotein (HDL) protects against myocardial ischemia-reperfusion (I/R) injury. Mammalian target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2) play opposing roles in protecting against I/R injury, whereby mTORC1 appears to be
Reham Al-Othman, Aishah Al-Jarallah, Fawzi Babiker   +2 more
doaj   +1 more source