Results 51 to 60 of about 162,144 (130)

Electroacupuncture at HT5 + GB20 produces stronger activation effect on swallowing cortex and muscle than single points. [PDF]

Heliyon, 2023
Fu X, Li H, Yang W, Li X, Lu L, Guo H, Wu Z, Guo K, Xu H, Huang Z.   +9 more
europepmc   +1 more source

Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice

Frontiers in Pharmacology
BackgroundStress is among the most common comorbid conditions with epilepsy and a strong factor in the pathophysiology of seizures. An imbalance in neuronal circuits causes recurrent unprovoked seizures in epilepsy. Dysregulation of BDNF/VEGF expression,
Jehan Zeb Khan, Syeda Rida Zainab, Mujeeb Ur Rehman, Muhammad Abid, Fawad Ali Shah, Najeeb Ur Rehman, Muhammad Khalid Tipu   +6 more
doaj   +1 more source

Model-Informed Precision Dosing of Isoniazid: Parametric Population Pharmacokinetics Model Repository

Drug Design, Development and Therapy
Gehang Ju,1– 3 Xin Liu,1– 3 Wenyu Yang,4 Nuo Xu,4 Lulu Chen,3,5 Chenchen Zhang,6 Qingfeng He,4 Xiao Zhu,4,* Dongsheng Ouyang1– 3,5,* 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People’s Republic of ...
Ju G, Liu X, Yang W, Xu N, Chen L, Zhang C, He Q, Zhu X, Ouyang D   +8 more
doaj  

Drug-induced hearing disorders: a disproportionality analysis of the FAERS database

Frontiers in Pharmacology
BackgroundTo evaluate and identify reports of adverse events related to hearing impairment with drugs approved in the past 20 years, to identify new adverse reaction signals related to hearing impairment that have not yet been reported, and to improve ...
Baojian Li, Xiaoling Hu, Zichen Yue
doaj   +1 more source

Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation

Journal of Inflammation
Transfer RNA-derived small RNAs (tsRNAs) are a newly discovered class of small noncoding RNAs (sncRNAs) that include tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs).
Peiru Qiu, Qi Jiang, Haojun Song
doaj   +1 more source

Eleutheroside B alleviates oxidative stress and neuroinflammation by inhibiting the JAK2/STAT3 signaling pathway in a rat high altitude cerebral edema model

Frontiers in Pharmacology
BackgroundHigh altitude cerebral edema (HACE) is a condition where the central nervous system experiences severe impairment as a result of sudden oxygen deprivation at high elevations.
Yacong He, Hongying Zhang, Xiu Zhang, Yue Han, Huxinyue Duan, Wenqian Song, Qingqing Tian, Yilan Wang, Guang Li, Chunjie Wu, Zhenxing Wang, Tianzhu Zhao   +11 more
doaj   +1 more source

Peculiar Phosphonate Modifications of Velvet Worm Slime Revealed by Advanced Nuclear Magnetic Resonance and Mass Spectrometry. [PDF]

J Am Chem Soc, 2023
Poulhazan A, Baer A, Daliaho G, Mentink-Vigier F, Arnold AA, Browne DC, Hering L, Archer-Hartmann S, Pepi LE, Azadi P, Schmidt S, Mayer G, Marcotte I, Harrington MJ.   +13 more
europepmc   +1 more source

From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy

Biomarker Research
The p53 protein, encoded by the TP53 gene, serves as a critical tumor suppressor, playing a vital role in maintaining genomic stability and regulating cellular responses to stress. Dysregulation of p53 is frequently observed in hematological malignancies,
Seyed Esmaeil Ahmadi, Elahe Rahimian, Samira Rahimi, Bahman Zarandi, Mehran Bahraini, Maral Soleymani, Seyed Mehrab Safdari, Ashkan Shabannezhad, Niloofar Jaafari, Majid Safa   +9 more
doaj   +1 more source

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

Frontiers in Pharmacology
Simultaneous inhibition of two or more pathways is playing a crucial role in the treatment of hepatocellular carcinoma with complex and diverse pathogenesis.
Yang Yang, Yuting Wang, Jing Chen, Miao-Miao Niu, Yongbin Wang, Xing Jin   +5 more
doaj   +1 more source

Electroacupuncture at HT5 + GB20 promotes brain remodeling and significantly improves swallowing function in patients with stroke. [PDF]

Front Neurosci, 2023
Fu X, Li H, Yang W, Li X, Lu L, Guo H, Guo K, Huang Z.   +7 more
europepmc   +1 more source