Results 31 to 40 of about 4,982 (186)

Structural Similarity of Human and Bovine Somatomedin Receptors and Human Insulin Receptor: Analysis by Affinity Labeling [PDF]

Pediatric Research, 1981
The growth promoting and insulin-like actions of somatomedin-C (Sm-C) are thought to be mediated respectively by interactions with the Sm-C and insulin (In) receptors. Since Sm-C and In are structurally homologous, we compared the size and subunit structure of their respective radiolabeled receptors in human placental membranes (hPM) and bovine ...
S Chernausek, S. B. Trippel, J J Van Wyk, S Jacobs   +3 more
openaire   +2 more sources

Proteomic exploration of potential blood biomarkers in haemophilic arthropathy

Health Science Reports, Volume 7, Issue 9, September 2024.
Abstract Background and Aims The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA. Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their ...
Nataša Kalebota, Ruđer Novak, Stela Hrkač, Porin Perić, Grgur Salai, Marko Močibob, Marija Pranjić, Zbyněk Zdráhal, Václav Pustka, Nadica Laktašić Žerjavić, Milan Milošević, Marijo Vodanović, Silva Zupančić Šalek, Lovorka Grgurević   +13 more
wiley   +1 more source

Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life [PDF]

, 1987
To determine the origin of estrogens in infant blood, we measured estrone (E1) and estradiol (E2) in the gonads of 50 girls and 64 boys who died suddenly between birth and 2 yr of age as well as in the adrenals of 18 of these infant girls and 16 of the ...
Bidlingmaier, F., Dorr, H. G., Eisenmenger, Wolfgang, Knorr, D., Strom, T. M.   +4 more
core   +1 more source

Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations

Aging Cell, Volume 23, Issue 9, September 2024.
This study examined the effects of metformin (MF) and trodusquemine (MSI‐1436) on the livers of young, developing mice. We discovered that MSI‐1436 significantly alters mRNA and miRNA expression more potently than MF, impacting key metabolic pathways.
Sarah A. Ashiqueali, Augusto Schneider, Xiang Zhu, Ewelina Juszczyk, Mishfak A. M. Mansoor, Yun Zhu, Yimin Fang, Bianka M. Zanini, Driele N. Garcia, Natalie Hayslip, David Medina, Samuel McFadden, Robert Stockwell, Rong Yuan, Andrzej Bartke, Michael Zasloff, Shadab Siddiqi, Michal M. Masternak   +17 more
wiley   +1 more source

Comparative Study of IGFBP Properties in Toad and Rat Sera [PDF]

, 1993
The levels ofIGF-Ihave been simultaneously measured byradioimmunoassayin samples of the toadBufo arenarumand of normal male Wistar rats. In addition, the different fractions of IGF-I binding proteins (IGFBP) and their binding properties have been ...
Braziunas, D., Cortizo, Ana María, Gagliardino, J.J., Jasper, H.   +3 more
core   +2 more sources

1179 MODULATION OF SOMATOMEDIN RECEPTOR SITES IN GROWTH HORMONE-TREATED HYPOPITUITARY DWARFS [PDF]

Pediatric Research, 1981
1179 MODULATION OF SOMATOMEDIN RECEPTOR SITES IN GROWTH HORMONE-TREATED HYPOPITUITARY ...
Ron G. Rosenfeld, Raymond L. Hintz, Stephen F. Kemp   +2 more
openaire   +2 more sources

Scale‐Dependent Rheology of Synovial Fluid Lubricating Macromolecules

Small, Volume 20, Issue 21, May 23, 2024.
A multiscale methodology using optical tweezers is developed to examine the interactions between hyaluronic acid (HA) and proteoglycan‐4 (PRG4/lubricin), which are major lubricating biomolecules of synovial fluid in the joints. For the first time, the length scale dependent structure and rheology in solution are characterized, providing a framework for
Leonardo Martin‐Alarcon, Aleksandra Govedarica, Randy H. Ewoldt, Steven L. Bryant, Gregory D. Jay, Tannin A. Schmidt, Milana Trifkovic   +6 more
wiley   +1 more source

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
core   +1 more source

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

Journal of Biological Chemistry, 1983
Phosphorylation of the somatomedin-C receptor was investigated both in intact IM-9 cells and in IM-9 cells that had been solubilized with Triton X-100. Intact IM-9 cells were incubated with [32P]H3PO4 for 1 h and for an additional 5 min in the absence or presence of insulin or somatomedin-C.
F C Kull, S Jacobs, Pedro Cuatrecasas, H. S. Earp, Marjorie E. Svoboda, J J Van Wyk   +5 more
openaire   +3 more sources

Proteoglycan 4 (PRG4) treatment improves skin wound healing in a porcine model

The FASEB Journal, Volume 38, Issue 6, 31 March 2024.
Proteoglycan 4 (PRG4) is commonly found in synovial fluid of the articular joint and serves as a boundary lubricant of articular cartilage. Interestingly, we show that human recombinant proteoglycan 4 (rhPRG4) improves healing of porcine full‐thickness skin injuries. rhPRG4 treatment decreases fibrosis, increases vascularization, and retains adipocytes
Nicoletta Ninkovic, Holly D. Sparks, Dragana Ponjevic, Greg Muench, Jeff A. Biernaskie, Roman J. Krawetz   +5 more
wiley   +1 more source