Results 81 to 90 of about 2,004 (138)
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Somatomedin/insulin-like growth factor tissue receptors.
Clinics in endocrinology and metabolism, 1984There are two types of Sm/IGF receptors based on results of competitive binding experiments and investigations of receptor structure. The type I receptor preferentially interacts with IGF I rather than IGF II and interacts weakly with insulin. This receptor has a binding subunit of Mr = 130 000 which is disulphide bonded to form larger structures of Mr
S P, Nissley, M M, Rechler
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Normal Somatomedin and Somatomedin Receptors in Achondroplastic Dwarfism
Hormone and Metabolic Research, 1980It has been proposed that the basic abnormality in achondroplasia may be a quantitative defect in endochondral new bone formation secondary to decreased synthesis of somatomedin (SM) or abnormal binding of SM to specific receptors. To test this hypothesis, we have measured plasma SM levels and SM receptors on circulating mononuclear cells obtained from
R G, Rosenfeld, R L, Hintz
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The somatomedin-C receptor of human placenta
Metabolism, 1984The binding and physical characteristics of the human placenta somatomedin-C (Sm-C) receptor were investigated and compared with those of the placental insulin receptor. These receptors were found to have many similar properties, but several distinctions exist between them. The two receptors have similar binding properties. Although distinct receptors,
C A, Stuart +2 more
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Size Discrepancy Between Somatomedin-C and Insulin Receptors*
The Journal of Clinical Endocrinology & Metabolism, 1984Somatomedin-C (Sm-C) and insulin receptors have similar size and structure. Each receptor is a heterotetramer composed two alpha- and two beta-subunits. Sodium dodecyl sulfate (SDS)-polyacrylamide gel autoradiographic studies of affinity labeled receptor preparations demonstrated that each has a whole receptor of greater than 350,000 daltons, a half ...
C A, Stuart +3 more
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Decrease in Serum Receptor-Reactive Somatomedin in Diabetes
Hormone and Metabolic Research, 1979Somatomedin in rat serum has been measured by a sensitive radioreceptor assay using 125I-labelled human somatomedin and human placental membrane. In rats made diabetic with strepotzotocin, receptor-reactive somatomedin levels were decrease by up to 75%. The decrease followed the time course of increasing serum glucose and occurred to the same extent in
R C, Baxter, A S, Brown, J R, Turtle
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Increased Somatomedin Receptor Sites in Newborn Circulating Mononuclear Cells*
The Journal of Clinical Endocrinology & Metabolism, 1979To evaluate the potential role of somatomedin as a growth factor in fetal development, we studied somatomedin receptors on circulating mononuclear cells from placental cord blood from 13 normal term newborns. Twelve healthy young adults served as controls.
R, Rosenfeld, A V, Thorsson, R L, Hintz
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Characterization of the human placental receptor for basic somatomedin
Canadian Journal of Biochemistry, 1982We have determined optimal conditions for the solubilization of the basic somatomedin (SM) receptor from human plancental membranes and for the measurement of the binding of basic SM to the solubilized receptor. Further, we have developed conditions under which the basic SM receptor, in the presence of equivalent amounts of insulin receptor, can be ...
B, Bhaumick +3 more
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Post-receptor actions of somatomedin on chondrocyte collagen biosynthesis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985The anabolic effects of human somatomedin C on freshly isolated Swarm chondrosarcoma chondrocytes were studied. Physiological concentrations (2-34 nM) of somatomedin, but not growth hormone, stimulated the incorporation of radiolabeled precursors into collagen and non-collagen proteins, RNA and proteoglycans.
D H, Willis, J P, Liberti
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Specific 125I-somatomedin receptor on circulating human mononuclear cells
Biochemical and Biophysical Research Communications, 1977Abstract Somatomedin is a growth hormone-stimulated peptide purified from plasma which has in vitro actions on cartilage and other tissues. Specific receptor sites for somatomedin distinct from insulin receptor sites have been described for many tissues.
A V, Thorsson, R L, Hintz
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Transferrin and somatomedin C receptors in the human ovarian follicles
Fertility and Sterility, 1987Transferrin and somatomedin C receptors (TFr and SMCr) were studied in human ovaries by immunostaining using monoclonal antisera. The oocyte of evoluting follicles was intensely positive for both types of receptors, but this positivity decreases in large follicles.
BALBONI, GIUSEPPE CARLO +4 more
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