Results 91 to 100 of about 2,004 (138)

Comparative studies on human placental insulin and basic somatomedin receptors

Journal of Cellular Biochemistry, 1982
AbstractThe disuccinimidy! suberate, affinity‐labeling procedure, and proteolytic mapping techniques have been employed to characterize further the human placental receptors for insulin and basic somatomedin. Electrophoretic analysis of the basic somatomedin receptor, selectively crosslinked to 125I basic somatomedin in the presence of excess native ...
G D, Armstrong, M D, Hollenberg, B, Bhaumick, R M, Bala   +3 more
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Ontogeny and Characterization of Basic Somatomedin Receptors in Rat Placenta*

Endocrinology, 1985
We investigated the binding of [125I]basic somatomedin (B-SM) (insulin-like growth factor-I/SM-C in rat placenta. Low but specific [125I]B-SM binding to placenta was detected in rats from the end of the second week (14 days) of gestation. The binding increased until about 17 days of gestation and then reached a plateau.
B, Bhaumick, R M, Bala
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Basic somatomedin (B-SM) receptors in human term placenta explants

Biochemical and Biophysical Research Communications, 1984
Binding of basic somatomedin (B-SM) and effect on alpha-aminoisobutyrate (AIB) uptake was studied in explants of term human placenta. B-SM demonstrated specific binding to the cultured explants. The binding was weakly inhibited by insulin. No significant degradation of the hormone was observed during incubation. The affinity cross-linking of [125I]B-SM
B, Bhaumick, R M, Bala
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Mouse Placental Receptor for Basic Somatomedin following Maternal Ethanol Administration

Developmental Pharmacology and Therapeutics, 1988
We have previously reported a reduction in the basic somatomedin (B-SM) binding activity of day-15 mouse placental membranes following 3 days of acute maternal ethanol administration. In the present experiments, we have investigated the effects of acute maternal ethanol administration early in gestation on the subsequent development of the placental B ...
L A, Kennedy, S, Mukerji, B, Bhaumick
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Somatomedin Action and Tissue Growth Factor Receptors

1987
The somatomedins (SMs) are a family of peptide hormones which are growth hormone (GH)-dependent, possess insulin-like activity in extra-skeletal tissue, and promote the incorporation of (35-S)-sulfate into proteoglycans of cartilage. Although their precise role in the control of cellular growth and replication is still unclear, a growing body of ...
Ron G. Rosenfeld, Gian Paolo Ceda, Darrell M. Wilson, Andrew R. Hoffman   +3 more
openaire   +1 more source

IGF-2 stimulated growth mediated by the somatomedin type 2 receptor

Biochemical and Biophysical Research Communications, 1987
Human Insulinlike Growth Factor 2 (IGF-2) can promote cell proliferation via the type 2 receptor in K562 cells, a human erythroleukemia cell line with IGF-2/type 2 receptors and insulin receptors but lacking IGF-1/type 1 receptors. Cells are grown in semi-solid agar in the absence and presence of increasing amounts of insulin, IGF-1 and IGF-2.
M, Tally, C H, Li, K, Hall
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Identification of a Receptor for Somatomedin-Like Polypeptides in Human Fibroblasts*

The Journal of Clinical Endocrinology & Metabolism, 1977
We have demonstrated a specific receptor for somatomedin-like growth polypeptides in human fibroblasts in culture using the closely related polypeptide, multiplication stimulating activity (MSA), as the radioligand. Polypeptides purified from human plasma, somatomedin A and acid soluble nonsuppressible insulin-like activity (NSILA-s), competed potently
M M, Rechler, S P, Nissley, J M, Podskalny, A C, Moses, L, Fryklund   +4 more
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Receptors for insulin and basic somatomedin: immunological and affinity-chromatographic cross-reactivity

Canadian Journal of Biochemistry and Cell Biology, 1983
Human placental receptors for insulin and for human basic somatomedin (BSM, analogous to human insulinlike growth factor I (IGF-I)) were selectively cross-link labelled with 125I-labelled insulin and BSM using disuccinimidyl suberate under conditions whereby cross-linking of 125I-labelled insulin to the BSM receptor and of 125I-labelled BSM to the ...
G D, Armstrong, M D, Hollenberg, B, Bhaumick, R M, Bala, J M, Maturo   +4 more
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Affinity-Labeled Somatomedin-C Receptors and Binding Proteins from the Human Fetus*

The Journal of Clinical Endocrinology & Metabolism, 1984
We investigated the ontogeny of the human placental membrane somatomedin-C (Sm-C)/insulin-like growth factor I (IGF-I) receptor by affinity labeling with the cross-linking agent disuccinimidyl suberate (DSS). Specific Sm-C receptors, identified from as early as 6 weeks gestation, demonstrated no apparent structural changes through the course of ...
J D, Grizzard, A J, D'Ercole, J R, Wilkins, B M, Moats-Staats, R W, Williams   +4 more
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Characterization of the Insulin and Somatomedin-C Receptors in Human Placental Cell Membranes

The Journal of Clinical Endocrinology & Metabolism, 1974
ABSTRACT Human placentas have been used to further investigate the binding of insulin and somatomedin to cell membrane receptors. Conditions for optimal binding of 125I-insulin were defined for both participate membrane preparations and membranes solubilized in Triton X-100. Human placental membranes are a rich source of high affinity insulin receptors.
R N, Marshall, L E, Underwood, S J, Voina, D B, Foushee, J J, Van Wyk   +4 more
openaire   +2 more sources