Results 91 to 100 of about 2,018 (137)
Some of the next articles are maybe not open access.
Increased Somatomedin Receptor Sites in Newborn Circulating Mononuclear Cells*
The Journal of Clinical Endocrinology & Metabolism, 1979To evaluate the potential role of somatomedin as a growth factor in fetal development, we studied somatomedin receptors on circulating mononuclear cells from placental cord blood from 13 normal term newborns. Twelve healthy young adults served as controls.
R, Rosenfeld, A V, Thorsson, R L, Hintz
openaire +2 more sources
Specific 125I-somatomedin receptor on circulating human mononuclear cells
Biochemical and Biophysical Research Communications, 1977Abstract Somatomedin is a growth hormone-stimulated peptide purified from plasma which has in vitro actions on cartilage and other tissues. Specific receptor sites for somatomedin distinct from insulin receptor sites have been described for many tissues.
A V, Thorsson, R L, Hintz
openaire +2 more sources
Comparative studies on human placental insulin and basic somatomedin receptors
Journal of Cellular Biochemistry, 1982AbstractThe disuccinimidy! suberate, affinity‐labeling procedure, and proteolytic mapping techniques have been employed to characterize further the human placental receptors for insulin and basic somatomedin. Electrophoretic analysis of the basic somatomedin receptor, selectively crosslinked to 125I basic somatomedin in the presence of excess native ...
G D, Armstrong +3 more
openaire +2 more sources
Canadian Journal of Biochemistry and Cell Biology, 1983
Human placental receptors for insulin and for human basic somatomedin (BSM, analogous to human insulinlike growth factor I (IGF-I)) were selectively cross-link labelled with 125I-labelled insulin and BSM using disuccinimidyl suberate under conditions whereby cross-linking of 125I-labelled insulin to the BSM receptor and of 125I-labelled BSM to the ...
G D, Armstrong +4 more
openaire +2 more sources
Human placental receptors for insulin and for human basic somatomedin (BSM, analogous to human insulinlike growth factor I (IGF-I)) were selectively cross-link labelled with 125I-labelled insulin and BSM using disuccinimidyl suberate under conditions whereby cross-linking of 125I-labelled insulin to the BSM receptor and of 125I-labelled BSM to the ...
G D, Armstrong +4 more
openaire +2 more sources
IGF-2 stimulated growth mediated by the somatomedin type 2 receptor
Biochemical and Biophysical Research Communications, 1987Human Insulinlike Growth Factor 2 (IGF-2) can promote cell proliferation via the type 2 receptor in K562 cells, a human erythroleukemia cell line with IGF-2/type 2 receptors and insulin receptors but lacking IGF-1/type 1 receptors. Cells are grown in semi-solid agar in the absence and presence of increasing amounts of insulin, IGF-1 and IGF-2.
M, Tally, C H, Li, K, Hall
openaire +2 more sources
Characterization of the Insulin and Somatomedin-C Receptors in Human Placental Cell Membranes
The Journal of Clinical Endocrinology & Metabolism, 1974ABSTRACT Human placentas have been used to further investigate the binding of insulin and somatomedin to cell membrane receptors. Conditions for optimal binding of 125I-insulin were defined for both participate membrane preparations and membranes solubilized in Triton X-100. Human placental membranes are a rich source of high affinity insulin receptors.
R N, Marshall +4 more
openaire +2 more sources
Basic somatomedin (B-SM) receptors in human term placenta explants
Biochemical and Biophysical Research Communications, 1984Binding of basic somatomedin (B-SM) and effect on alpha-aminoisobutyrate (AIB) uptake was studied in explants of term human placenta. B-SM demonstrated specific binding to the cultured explants. The binding was weakly inhibited by insulin. No significant degradation of the hormone was observed during incubation. The affinity cross-linking of [125I]B-SM
B, Bhaumick, R M, Bala
openaire +2 more sources
Characterization of the binding of a rat somatomedin to receptors in human placental cell membranes
Biochemical and Biophysical Research Communications, 1979Abstract The somatomedins presumably initiate their growth promoting effects by first binding to specific cell surface receptors in responsive tissues. The specific and high affinity binding of [125I]-rat somatomedin to human placental membranes was saturable and reversible with a dissociation constant of 4.5 × 10−9 M calculated from Scatchard ...
J W, Jacobs +3 more
openaire +2 more sources
Somatomedin Action and Tissue Growth Factor Receptors
1987The somatomedins (SMs) are a family of peptide hormones which are growth hormone (GH)-dependent, possess insulin-like activity in extra-skeletal tissue, and promote the incorporation of (35-S)-sulfate into proteoglycans of cartilage. Although their precise role in the control of cellular growth and replication is still unclear, a growing body of ...
Ron G. Rosenfeld +3 more
openaire +1 more source
Mouse Placental Receptor for Basic Somatomedin following Maternal Ethanol Administration
Developmental Pharmacology and Therapeutics, 2017We have previously reported a reduction in the basic somatomedin (B-SM) binding activity of day-15 mouse placental membranes following 3 days of acute maternal ethanol administration. In the present experiments, we have investigated the effects of acute maternal ethanol administration early in gestation on the subsequent development of the placental B ...
L A, Kennedy, S, Mukerji, B, Bhaumick
openaire +2 more sources