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Normal Somatomedin and Somatomedin Receptors in Achondroplastic Dwarfism

Hormone and Metabolic Research, 1980
It has been proposed that the basic abnormality in achondroplasia may be a quantitative defect in endochondral new bone formation secondary to decreased synthesis of somatomedin (SM) or abnormal binding of SM to specific receptors. To test this hypothesis, we have measured plasma SM levels and SM receptors on circulating mononuclear cells obtained from
R G, Rosenfeld, R L, Hintz
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The somatomedin-C receptor of human placenta

Metabolism, 1984
The binding and physical characteristics of the human placenta somatomedin-C (Sm-C) receptor were investigated and compared with those of the placental insulin receptor. These receptors were found to have many similar properties, but several distinctions exist between them. The two receptors have similar binding properties. Although distinct receptors,
C A, Stuart   +2 more
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Decrease in Serum Receptor-Reactive Somatomedin in Diabetes

Hormone and Metabolic Research, 1979
Somatomedin in rat serum has been measured by a sensitive radioreceptor assay using 125I-labelled human somatomedin and human placental membrane. In rats made diabetic with strepotzotocin, receptor-reactive somatomedin levels were decrease by up to 75%. The decrease followed the time course of increasing serum glucose and occurred to the same extent in
R C, Baxter, A S, Brown, J R, Turtle
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Characterization of the human placental receptor for basic somatomedin

Canadian Journal of Biochemistry, 1982
We have determined optimal conditions for the solubilization of the basic somatomedin (SM) receptor from human plancental membranes and for the measurement of the binding of basic SM to the solubilized receptor. Further, we have developed conditions under which the basic SM receptor, in the presence of equivalent amounts of insulin receptor, can be ...
B, Bhaumick   +3 more
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Transferrin and somatomedin C receptors in the human ovarian follicles

Fertility and Sterility, 1987
Transferrin and somatomedin C receptors (TFr and SMCr) were studied in human ovaries by immunostaining using monoclonal antisera. The oocyte of evoluting follicles was intensely positive for both types of receptors, but this positivity decreases in large follicles.
BALBONI, GIUSEPPE CARLO   +4 more
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Ontogeny and Characterization of Basic Somatomedin Receptors in Rat Placenta*

Endocrinology, 1985
We investigated the binding of [125I]basic somatomedin (B-SM) (insulin-like growth factor-I/SM-C in rat placenta. Low but specific [125I]B-SM binding to placenta was detected in rats from the end of the second week (14 days) of gestation. The binding increased until about 17 days of gestation and then reached a plateau.
B, Bhaumick, R M, Bala
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Identification of a Receptor for Somatomedin-Like Polypeptides in Human Fibroblasts*

The Journal of Clinical Endocrinology & Metabolism, 1977
We have demonstrated a specific receptor for somatomedin-like growth polypeptides in human fibroblasts in culture using the closely related polypeptide, multiplication stimulating activity (MSA), as the radioligand. Polypeptides purified from human plasma, somatomedin A and acid soluble nonsuppressible insulin-like activity (NSILA-s), competed potently
M M, Rechler   +4 more
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