Results 121 to 130 of about 537,907 (152)
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Size Discrepancy Between Somatomedin-C and Insulin Receptors*
The Journal of Clinical Endocrinology & Metabolism, 1984Somatomedin-C (Sm-C) and insulin receptors have similar size and structure. Each receptor is a heterotetramer composed two alpha- and two beta-subunits. Sodium dodecyl sulfate (SDS)-polyacrylamide gel autoradiographic studies of affinity labeled receptor preparations demonstrated that each has a whole receptor of greater than 350,000 daltons, a half ...
C A, Stuart +3 more
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Post-receptor actions of somatomedin on chondrocyte collagen biosynthesis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985The anabolic effects of human somatomedin C on freshly isolated Swarm chondrosarcoma chondrocytes were studied. Physiological concentrations (2-34 nM) of somatomedin, but not growth hormone, stimulated the incorporation of radiolabeled precursors into collagen and non-collagen proteins, RNA and proteoglycans.
D H, Willis, J P, Liberti
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Somatomedin/insulin-like growth factor tissue receptors.
Clinics in endocrinology and metabolism, 1984There are two types of Sm/IGF receptors based on results of competitive binding experiments and investigations of receptor structure. The type I receptor preferentially interacts with IGF I rather than IGF II and interacts weakly with insulin. This receptor has a binding subunit of Mr = 130 000 which is disulphide bonded to form larger structures of Mr
S P, Nissley, M M, Rechler
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Increased Somatomedin Receptor Sites in Newborn Circulating Mononuclear Cells*
The Journal of Clinical Endocrinology & Metabolism, 1979To evaluate the potential role of somatomedin as a growth factor in fetal development, we studied somatomedin receptors on circulating mononuclear cells from placental cord blood from 13 normal term newborns. Twelve healthy young adults served as controls.
R, Rosenfeld, A V, Thorsson, R L, Hintz
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Comparative studies on human placental insulin and basic somatomedin receptors
Journal of Cellular Biochemistry, 1982AbstractThe disuccinimidy! suberate, affinity‐labeling procedure, and proteolytic mapping techniques have been employed to characterize further the human placental receptors for insulin and basic somatomedin. Electrophoretic analysis of the basic somatomedin receptor, selectively crosslinked to 125I basic somatomedin in the presence of excess native ...
G D, Armstrong +3 more
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Specific 125I-somatomedin receptor on circulating human mononuclear cells
Biochemical and Biophysical Research Communications, 1977Abstract Somatomedin is a growth hormone-stimulated peptide purified from plasma which has in vitro actions on cartilage and other tissues. Specific receptor sites for somatomedin distinct from insulin receptor sites have been described for many tissues.
A V, Thorsson, R L, Hintz
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Canadian Journal of Biochemistry and Cell Biology, 1983
Human placental receptors for insulin and for human basic somatomedin (BSM, analogous to human insulinlike growth factor I (IGF-I)) were selectively cross-link labelled with 125I-labelled insulin and BSM using disuccinimidyl suberate under conditions whereby cross-linking of 125I-labelled insulin to the BSM receptor and of 125I-labelled BSM to the ...
G D, Armstrong +4 more
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Human placental receptors for insulin and for human basic somatomedin (BSM, analogous to human insulinlike growth factor I (IGF-I)) were selectively cross-link labelled with 125I-labelled insulin and BSM using disuccinimidyl suberate under conditions whereby cross-linking of 125I-labelled insulin to the BSM receptor and of 125I-labelled BSM to the ...
G D, Armstrong +4 more
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IGF-2 stimulated growth mediated by the somatomedin type 2 receptor
Biochemical and Biophysical Research Communications, 1987Human Insulinlike Growth Factor 2 (IGF-2) can promote cell proliferation via the type 2 receptor in K562 cells, a human erythroleukemia cell line with IGF-2/type 2 receptors and insulin receptors but lacking IGF-1/type 1 receptors. Cells are grown in semi-solid agar in the absence and presence of increasing amounts of insulin, IGF-1 and IGF-2.
M, Tally, C H, Li, K, Hall
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Characterization of the Insulin and Somatomedin-C Receptors in Human Placental Cell Membranes
The Journal of Clinical Endocrinology & Metabolism, 1974ABSTRACT Human placentas have been used to further investigate the binding of insulin and somatomedin to cell membrane receptors. Conditions for optimal binding of 125I-insulin were defined for both participate membrane preparations and membranes solubilized in Triton X-100. Human placental membranes are a rich source of high affinity insulin receptors.
R N, Marshall +4 more
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Basic somatomedin (B-SM) receptors in human term placenta explants
Biochemical and Biophysical Research Communications, 1984Binding of basic somatomedin (B-SM) and effect on alpha-aminoisobutyrate (AIB) uptake was studied in explants of term human placenta. B-SM demonstrated specific binding to the cultured explants. The binding was weakly inhibited by insulin. No significant degradation of the hormone was observed during incubation. The affinity cross-linking of [125I]B-SM
B, Bhaumick, R M, Bala
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