Significant down-regulation of growth hormone receptor expression revealed as a new unfavorable prognos- tic factor in hepatitis C virus-related hepatocellular carcinoma [PDF]
Clinical and Molecular Hepatology, 2021 Background/Aims Growth hormone (GH) is the main regulator of somatic growth, metabolism, and gender dimorphism in the liver. GH receptor (GHR) signaling in cancer is derived from a large body of evidence, although the GHR signaling pathway involved in ...
Ching-Chih Lin +9 more
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Somatostatin and Its Receptor System in Colorectal Cancer
Biomedicines, 2021 Somatostatin (SST)/somatotropin release-inhibiting factor (SRIF) is a well-known neuropeptide, widely distributed in the central and peripheral nervous systems, that regulates the endocrine system and affects neurotransmission via interaction with five ...
Aldona Kasprzak
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Biology, 2023 Multiple studies have reported new or exacerbated persistent or resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates resistant ...
David Kartchner +7 more
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Structures of the somatotropin receptor and prolactin receptor on rat hepatocytes characterized by affinity labelling [PDF]
Biochemical Journal, 1984 Human somatotropin competed for 125I-human somatotropin binding to hepatocytes from female or male rats. Bovine somatotropin and prolactin each inhibited part, but not all, of the uptake of 125I-human somatotropin. The binding of 125I-prolactin was inhibited by human somatotropin and prolactin, but not by bovine somatotropin.
K, Yamada, D B, Donner
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Molecular Brain, 2021 Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs), and, in turn, provide feedback inhibition onto PC dendrites.
Anne-Sophie Racine +3 more
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Characterization of human somatotropin binding to detergent-solubilized lactogenic receptors from rat liver [PDF]
Biochemical Journal, 1981 Lactogenic receptors from rat liver microsomal fraction (‘microsomes’) were extracted by treatment with 1% (w/v) Triton X-100. Triton X-100 exerts an inhibitory effect on both the binding reaction and the separation of the free hormone from the complex.
J S, Bonifacino +2 more
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Immunohistochemical and Nucleic Acid Analysis of Somatotropin Receptor Populations in the Bovine Ovary [PDF]
Biology of Reproduction, 1993 Ovaries were analyzed for somatotropin receptor protein and mRNA through use of immunohistochemistry, solution hybridization/nuclease protection, Northern blotting, and reverse transcriptase polymerase chain reaction (RT-PCR). As indicated by immunoperoxidase staining, CL expressed immunoreactive somatotropin receptor (positive stain).
M C, Lucy +5 more
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Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2016 Insulin-like growth factors control numerous processes, namely somatic growth, metabolism and stress resistance, connecting this pathway to aging and age-related diseases. Insulin-like growth factor signaling also impacts on neurogenesis, neuronal survival and structural plasticity.
Daniel de Magalhaes Filho, C. +14 more
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Melatonin – apleiotropic hormone
Pediatria i Medycyna Rodzinna, 2016 Melatonin, a tryptophan derivative, is synthesised in mammals mainly in the pineal gland. It coordinates the biological clock by regulating the circadian rhythm. Its production is dependent on light and its concentrations change with age. Thanks to its
Maciej Brzęczek +2 more
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Effect of bovine somatotropin on neutrophil functions and clinical symptoms during Streptococcus uberis mastitis. [PDF]
, 1999 The effect of recombinant bovine somatotropin (bST) on the chemiluminescence, diapedesis, and expression of adhesion receptors (CD11a, CD11b, CD18) of isolated polymorphonuclear leukocytes was studied.
Burvenich, Christian +4 more
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