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The Journal of Steroid Biochemistry and Molecular Biology, 1994
The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
S, Schwarz, P, Pohl
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The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
S, Schwarz, P, Pohl
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1991
In the three decades since the original discovery of receptors for steroid hormones, much has been learned about the biochemical processes by which these regulatory agents exert their effects in target tissues. The intracellular receptor proteins are potential transcription factors, needed for optimal gene expression in hormone-dependent cells.
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In the three decades since the original discovery of receptors for steroid hormones, much has been learned about the biochemical processes by which these regulatory agents exert their effects in target tissues. The intracellular receptor proteins are potential transcription factors, needed for optimal gene expression in hormone-dependent cells.
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Steroid Receptors in Osteoblasts
Clinical Orthopaedics and Related Research, 1980Using the whole-cell incubation system at 37 degrees C, the specific bindings for 3H-dexamethasone, 3H-estradiol-17 beta, 3H-dihydrotestosterone and 3H-R5020 were measured in the purified, putative osteoblasts isolated from fetal rat calvaria by collagenase digestion.
T, Yoshioka +3 more
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Steroids, steroid receptors and disease
Trends in Molecular Medicine, 2001Abstract The 672nd Biochemical Society meeting was held at Sussex University, UK, from 19 to 21 December 2000. One session was dedicated to the study of steroids and their receptors, and related diseases.
Helen Wiseman, Rosanna Duffy
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Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Nature Reviews Drug Discovery, 2004A. Norman +2 more
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Steroid Receptor Coactivator Peptidomimetics
2003Publisher Summary This chapter focuses on the methods that are useful for designing and synthesizing a series of coactivator peptidomimetics (axXXbxcx) of the L1XXL2L3 sequence to identify specific inhibitors of particular hormone receptor (NR)–coactivator interactions.
Timothy R, Geistlinger, R Kiplin, Guy
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Current Opinion in Cell Biology, 1993
Steroid hormone receptors stimulate gene transcription by binding to DNA as homodimers, whereas many other members of the nuclear receptor family appear to function as heterodimers or as monomers. This is important for target gene recognition and, given that many of the receptors are expressed in multiple forms, generates many combinations of ligand ...
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Steroid hormone receptors stimulate gene transcription by binding to DNA as homodimers, whereas many other members of the nuclear receptor family appear to function as heterodimers or as monomers. This is important for target gene recognition and, given that many of the receptors are expressed in multiple forms, generates many combinations of ligand ...
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Steroid/nuclear receptor coactivators
2000In higher eukaryotes, steroids/thyroid hormones and many lipophilic compounds regulate cellular physiology through binding to the steroid/nuclear receptor proteins. Steroid/nuclear receptors are ligand-dependent transcriptional activators that can stimulate gene expression.
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2000
Steroid hormones, after binding to their receptors, regulate a large number of physiological processes including development, growth, metabolism, and reproduction and fertility (1,2). Target tissues include those involved in sexual development and reproduction such as the gonads, uterus, epididymis, and pituitary, as well as the brain, bone, and liver.
Derek A. Schreihofer +2 more
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Steroid hormones, after binding to their receptors, regulate a large number of physiological processes including development, growth, metabolism, and reproduction and fertility (1,2). Target tissues include those involved in sexual development and reproduction such as the gonads, uterus, epididymis, and pituitary, as well as the brain, bone, and liver.
Derek A. Schreihofer +2 more
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JAMA: The Journal of the American Medical Association, 1977
J A, Holt, T A, Caputo, K M, Kelly
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J A, Holt, T A, Caputo, K M, Kelly
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