Results 261 to 270 of about 798,182 (300)

Steroid Receptors in Intracranial Tumors

Clinical Neuropharmacology, 1984
Cytosolic estrogen (ER), progesterone (PR), androgen (AR), and glucocorticoid (GR) receptors were evaluated in 6 meningiomas and 12 gliomas (6 astrocytomas and 6 glioblastomas) using a dextran-coated charcoal method. Thirty-three percent (two) of the meningiomas and 17% (two) of the gliomas contained positive (greater than or equal to 10 fmol/mg ...
M M, Brentani, M T, Lopes, V R, Martins, J P, Plese   +3 more
openaire   +2 more sources

Cdc25B as a Steroid Receptor Coactivator

2004
The traditional role of the Cdc25 family of dual-specificity phosphatases is to activate cyclin-dependent kinases (CDKs) to enable progression through the cell cycle. This chapter reports that in addition to its cell cycle role, Cdc25B functions as a novel steroid receptor coactivator (SRC).
Ngan, E, Ma, Z, Tsai, SY, Chua, SS
openaire   +4 more sources

Human kidney steroid receptors

Journal of Steroid Biochemistry, 1976
Abstract Saturation analyses, binding kinetics and agar gel electrophoresis performed on normal human kidney tissue revealed the presence of a specific progesterone receptor in all the specimens studied and in one, a specific estradiol receptor was observed, Progesterone binding had a rapid association and a slow dissociation reaction.
G, Concolino, A, Marocchi, F, Concolino, F, Sciarra, F, Di Silverio, C, Conti   +5 more
openaire   +2 more sources

Steroid hormones and their receptors in the brain

The Journal of Steroid Biochemistry and Molecular Biology, 1998
Steroid hormones regulate several important functions of the brain by altering the expression of particular genes through their receptors. First in this paper the localization of glucocorticoid receptor immunoreactivity and mRNA in the brain was examined. Second biphasic effects of glucocorticoid on the hippocampus was described and particular emphasis
M, Kawata, K, Yuri, H, Ozawa, M, Nishi, T, Ito, Z, Hu, H, Lu, M, Yoshida   +7 more
openaire   +2 more sources

Steroid receptors in sarcomatous lesions

Journal of Surgical Oncology, 1979
AbstractClinical observations showed that the natural history of sarcomatous lesions may be different among males and females, and it may be influenced by hormonal factors. Estrogen receptors (ER) were measured on biopsy specimens of melanoma (two patients), soft‐tissue sarcoma (four patients), cystosarcoma phylloides (five patients), benign breast ...
Y T, Lee, F S, Markland
openaire   +2 more sources

Steroid Receptor Coactivator Peptidomimetics

2003
Publisher Summary This chapter focuses on the methods that are useful for designing and synthesizing a series of coactivator peptidomimetics (axXXbxcx) of the L1XXL2L3 sequence to identify specific inhibitors of particular hormone receptor (NR)–coactivator interactions.
Timothy R, Geistlinger, R Kiplin, Guy
openaire   +2 more sources

Steroid Receptors

JAMA: The Journal of the American Medical Association, 1977
J A, Holt, T A, Caputo, K M, Kelly
openaire   +2 more sources

Non-steroidal steroid receptor modulators.

IDrugs : the investigational drugs journal, 2006
The discovery and launch of non-steroidal ligands for estrogen receptors (ERs) and for androgen receptors (ARs) demonstrated the potential of these ligands as therapeutic agents. Based on these successes, substantial attention in the past ten years has been focused on identifying non-steroidal ligands for all of the classic steroid receptors.
Pedro H H, Hermkens, Sarah, Kamp, Scott, Lusher, Gerrit H, Veeneman   +3 more
openaire   +1 more source

Steroid Receptors and Breast Cancer

Hospital Practice, 1980
Endocrine therapy can significantly prolong life in about a third of patients with advanced mammary carcinoma, but until recently it has been impossible to predict which ones. Assays for receptors specific for estrogen and progesterone have made the predictive process more accurate, and antiestrogens are providing the basis for a new approach to ...
openaire   +2 more sources

Nucleocytoplasmic Shuttling of Steroid Receptors

1995
Publisher Summary This chapter elaborates the nucleocytoplasmic shuttling of steroid receptors. The activity of various steroid receptors hormone-independent nuclear localization signal sequences (NLSs) is suppressed, in cis, by the unoccupied glucocorticoid receptors ligand binding domain (GR LBD).
D B, Defranco, A P, Madan, Y, Tang, U R, Chandran, N, Xiao, J, Yang   +5 more
openaire   +2 more sources