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Steroids, steroid receptors and disease
Trends in Molecular Medicine, 2001Abstract The 672nd Biochemical Society meeting was held at Sussex University, UK, from 19 to 21 December 2000. One session was dedicated to the study of steroids and their receptors, and related diseases.
Helen Wiseman, Rosanna Duffy
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STEROID HORMONES AND THEIR RECEPTORS
Journal of Endocrinology, 1973Abstract INTRODUCTION It is believed that in target tissues steroid hormones are bound by cytoplasmic receptors* of high affinity and specificity; that the steroid receptor complex moves to the nucleus where physiological changes are initiated via a modification of genetic ...
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Current Opinion in Cell Biology, 1993
Steroid hormone receptors stimulate gene transcription by binding to DNA as homodimers, whereas many other members of the nuclear receptor family appear to function as heterodimers or as monomers. This is important for target gene recognition and, given that many of the receptors are expressed in multiple forms, generates many combinations of ligand ...
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Steroid hormone receptors stimulate gene transcription by binding to DNA as homodimers, whereas many other members of the nuclear receptor family appear to function as heterodimers or as monomers. This is important for target gene recognition and, given that many of the receptors are expressed in multiple forms, generates many combinations of ligand ...
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Reconstitution of the Steroid Receptor Heterocomplex
2019Steroid receptors are members of a subfamily of the nuclear receptor superfamily. They play a dual role of steroid hormone receptors and transcription factors. Actually, these receptors are steroid-activated transcription factors. Classical soluble receptors exist as oligomeric complexes with the Hsp90-based chaperone machinery.
Mazaira, Gisela Ileana +1 more
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Sex steroids and their receptors in lampreys
Steroids, 2008The use of steroids and their receptors as ligand-gated transcription factors is thought to be an important step in vertebrate evolution. The lamprey is the earliest-evolving vertebrate to date in which sex steroids and their receptors have been demonstrated to have hormonal roles similar to those found in jawed vertebrates.
Mara B, Bryan +2 more
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Steroid flexibility and receptor specificity
Journal of Steroid Biochemistry, 1980Unsaturated Δ4,9 and Δ4,9,11 steroid hormones with a keto group in position 3 and a hydroxy, lactone or oxathiolane function in 17β, with or without methyl substituents in positions 17α, 18 and/or 7α, tend to compete significantly for specific binding to the receptor proteins corresponding to several steroid hormone classes (progestin, androgen ...
J, Delettré +4 more
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Steroid Receptors in Breast Cancer
Archives of Internal Medicine, 1982Since the report by Beatson1in 1896 of human mammary tumor regression occurring after bilateral oophorectomy, much interest has developed in the hormonal dependence of these tumors. Subsequently, it has been shown that a wide variety of both ablative, eg, adrenalectomy and hypophysectomy, and additive, eg, estrogen, progestin, androgen, and ...
K, Cowan, M, Lippman
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1991
In the three decades since the original discovery of receptors for steroid hormones, much has been learned about the biochemical processes by which these regulatory agents exert their effects in target tissues. The intracellular receptor proteins are potential transcription factors, needed for optimal gene expression in hormone-dependent cells.
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In the three decades since the original discovery of receptors for steroid hormones, much has been learned about the biochemical processes by which these regulatory agents exert their effects in target tissues. The intracellular receptor proteins are potential transcription factors, needed for optimal gene expression in hormone-dependent cells.
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RECEPTORS AND STEROID‐DEPENDENT HYPERTENSION
Clinical and Experimental Pharmacology and Physiology, 1988SUMMARY1. Repeated observations indicate that ACTH administration causes hypertension.2. Development of hypertension requires 17α‐hydroxyprogesterone and 17α, 20α‐dihydroxy‐4‐pregnene‐3‐one to be present in association with other steroids.3. The hypertensinogenic activity of corticosteroids is distinct from their glucocorticoid and mineralocorticoid ...
J P, Coghlan +4 more
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Steroid Receptors in Human Meningioma
Clinical Neuropharmacology, 1984It is well recognised that there is an increased frequency of meningioma in women compared with men and that rapid progression of the disease may occur during pregnancy. Recent studies have demonstrated steroid receptors in human meningioma. In this study we have looked for the presence of nuclear and cytoplasmic estrogen receptor (ER) and cytoplasmic ...
E, Hayward +3 more
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