Results 151 to 160 of about 78,914 (316)

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

The FEBS Journal, EarlyView.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis, Abibe Useini, Heike Betat, Sonja Bonin, Helen Broghammer, Rima Nuwayhid, Stefan Langer, Mario Mörl, Norbert Sträter, John T. Heiker   +9 more
wiley   +1 more source

The predictive role of protease-activated receptor (PAR-1) polymorphisms and activated microplatelets on the severity of atherosclerosis - preliminary studies. [PDF]

Front Mol Biosci
Jakobsche-Policht U, Bronowicka-Szydełko A, Adamiec R, Bednarska-Chabowska D, Lewandowski Ł, Małecki R, Gostomska-Pampuch K, Adamiec-Mroczek J, Myszka-Kozłowska M, Baczyńska D, Rabczyński M, Kuźnik E, Polański J, Martynowicz H, Dolińska D, Matlak P, Sobczyńska J, Ziomek M, Tota M, Stach W, Madziarska K.   +20 more
europepmc   +1 more source

TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation

The FEBS Journal, EarlyView.
TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni, Lucia Merolle, Agnese Razzoli, Eleonora Maurizi, Gaia Gavioli, Roberto Baricchi, Chiara Marraccini, Davide Schiroli   +7 more
wiley   +1 more source

The role of protease-activated receptors (PARs) in the functioning of platelets and platelet-derived microparticles (PMPs). [PDF]

Front Mol Biosci
Jakobsche-Policht U, Bronowicka-Szydełko A, Adamiec R, Bednarska-Chabowska D, Mierzchała-Pasierb M, Lewandowski Ł, Gostomska-Pampuch K, Adamiec-Mroczek J, Rabczyński M, Kuźnik E, Lubieniecki P, Dróżdż O, Martynowicz H, Kwiecień A, Strzelecka M, Rudkiewicz D, Piersiak M, Ziomek M, Kondracki M, Galińska Z, Madziarska K.   +20 more
europepmc   +1 more source

Acceptability and Determinants for Implementation of the EnzySystem, a Novel Near‐Patient Testing Platform for Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Coagulation testing in haemophilia A is limited by the scarcity of testing facilities capable of performing relevant assays. This issue incentivized the development of the EnzySystem for haemophilia A, a near‐patient testing platform aimed to measure Factor VIII activity and thrombin generation simultaneously within 1 h from 100 ...
Aernoud P. Bavinck, Kyle Davis, Lisa van Engelshoven, Monique G. van Lier, Tanja Hamacher, Nicole M. A. Blijlevens, Amy Shapiro, Saskia E. M. Schols, Waander L. van Heerde   +8 more
wiley   +1 more source

BindFlow: A Free, User-Friendly Pipeline for Absolute Binding Free Energy Calculations Using Free Energy Perturbation or MM(PB/GB)SA. [PDF]

J Chem Theory Comput
León AM, Andersen L, Hub JS.
europepmc   +1 more source

Investigation of the Suitability of the ROTEM Assay to Measure Coagulation Potential in Blood From Patients on Concizumab Prophylaxis

Haemophilia, EarlyView.
ABSTRACT Background Rotational thromboelastometry (ROTEM) aims to measure the coagulation potential in whole blood. Concizumab, an anti‐tissue factor pathway inhibitor (TFPI) antibody for prophylaxis in haemophilia, enhances tissue factor (TF)‐initiated coagulation by preventing inhibition of activated factor X (FXa), thus increasing thrombin ...
Hermann Eichler, Nora V. Butta, Anne Riddell, Cecilia Augustsson, Marianne Kjalke, Kasper Jensen, Andrea Paramo‐Florencio, Jan Astermark, Pratima Chowdary, Victor Jiménez‐Yuste   +9 more
wiley   +1 more source

Functional toll-like receptor 4 links endotoxin sensing to platelet priming in feline platelets. [PDF]

Front Vet Sci
Li RHL, Shaverdian M, Chen C, Stuhlmann C, Stern JA, Nguyen N.   +5 more
europepmc   +1 more source

Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction There are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the ...
Siraj Mithoowani, Chee Wee Tan, Deborah M. Siegal   +2 more
wiley   +1 more source