Results 161 to 170 of about 42,405 (307)

Hemostasis at the edge between physiology and cancer. [PDF]

Intern Emerg Med
Galardi A, Dell'Orto E, Bianchi F, Cosentino G, Fogazzi V, Pupa SM, Iorio MV.   +6 more
europepmc   +1 more source

Modulation of thrombin receptor signaling

, 2013
The platelet thrombin receptors Protease-activated receptor 1 (PAR1) and Protease activated receptor 4 (PAR4) stand at the intersection of coagulation and platelet activation.
Young, Summer Elizabeth
core  

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

High thrombin activity associated with crohn's disease induces microbiota pathogenicity contributing to mucosal inflammation. [PDF]

Gut Microbes
Le Cosquer G, Pannier M, Thevenin J, Guiraud L, David M, Dumas A, Meunier E, Rousset P, Palese S, Giorgio C, Buscail L, Bournet B, Gilletta C, Culetto A, Canivet C, Buscail E, Camaré C, Alric L, Deraison C, Vergnolle N, Motta JP.   +20 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Platelet mitochondria dysfunction in diabetes mellitus: mechanisms and therapeutic implications. [PDF]

Front Pharmacol
Yadava S, Dontiboina HR, Dugluri S, Yadagiri G, Choudhury P, Kakarla R.   +5 more
europepmc   +1 more source

The role of platelet thrombin receptors PAR1 and PAR4 in platelet activation

, 2009
Platelets play a pivotal role in coagulation and haemostasis. Their most prominent task is to seal damaged blood vessels by the formation of a platelet plug at the damaged area.
Vretenbrant Öberg, Karin
core  

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Effects of transcutaneous auricular vagus nerve stimulation or combined vagal and trigeminal nerve stimulation on platelet function and laboratory hemostasis parameters in healthy human subjects. [PDF]

Bioelectron Med
Huston JM, Bravo-Iñiguez CE, Papoin J, Ahmad M, Le B, Mirro I, McWade M, Benner C, Covalin A, Czura CJ, Khodaparast N, Blanc L.   +11 more
europepmc   +1 more source

Characterisation and functional activity of thrombin receptors in the human lens

, 2003
Purpose: Activation of thrombin receptors affects many diverse cellular functions including inhibition of active sodium-potassium transport in the pig lens.
James, C., Duncan, G., Collison, D.J.
core