Results 251 to 260 of about 42,405 (307)

Thrombin receptor-activating peptide sensitizes the human endothelial thrombin receptor

American Journal of Physiology-Cell Physiology, 1995
Receptor-operated effects of alpha-thrombin and of the thrombin receptor-activating peptide TRAP14 on cytoplasmic Ca2+ concentration ([Ca2+]i) were examined in fura 2-loaded endothelial cells. Experiments with hirudin showed that alpha-thrombin-induced Ca2+ influx requires the continuous presence of active alpha-thrombin.
H J, Kruse, C, Mayerhofer, W, Siess, P C, Weber   +3 more
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The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective? [PDF]

Journal of Neurochemistry, 2003
In the last two decades it has become apparent that thrombin has many extravascular effects that are mediated by a family of protease-activated receptors (PARs). PAR-1, -3 and -4 are activated via cleavage by thrombin.
Guohua Xi, Richard F Keep
exaly   +2 more sources

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THE THROMBIN RECEPTOR

Clinical and Experimental Pharmacology and Physiology, 1994
SUMMARY1. The thrombin receptor has now been cloned and found to be a member of the G‐protein‐coupled seven‐transmembrane domain receptor family.2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor‐derived peptides have demonstrated that this receptor may be the one responsible ...
P M, Dennington, M C, Berndt
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Platelet Receptors for Thrombin

1985
Platelets are activated by many different agonists, lach agonist presumably acts on a different receptor, but in no case has a receptor been defined1. Thrombin is perhaps the most potent physiological platelet agonist. In this paper, we review the current state of knowledge of the mechanism of thrombin-induced platelet activation. Results of studies of
T C, Detwiler, E B, McGowan
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Thrombin Receptor Antagonists

Seminars in Thrombosis and Hemostasis, 1996
Thrombin's proteolytically activated "tethered-ligand" receptor is widely expressed and mediates many of thrombin's actions on cells. Its central role in thrombin-stimulated human platelet activation and vascular smooth muscle proliferation as well as location in atherosclerotic plaques suggests receptor involvement in arterial thrombosis and ...
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Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation

Thrombosis and Haemostasis, 1997
Thrombin mediates acute vascular thrombosis and subsequent vascular lesion formation following mechanical denuding injury or spontaneous atherosclerotic plaque rupture. In the process of generating thrombin Factor VII/VIIa binds avidly with tissue factor (TF) exposed on cellular membranes, and coagulation serine proteases are sequentially cleaved via ...
L A, Harker, S R, Hanson, A B, Kelly
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The Thrombin Receptor in the Nervous System

Seminars in Thrombosis and Hemostasis, 1996
Neurite retraction and reversal of astrocyte stellation triggered by the serine protease thrombin are receptor-mediated events. This article summarizes the current knowledge about the cellular effects that are induced by thrombin and its receptor in neural cells.
Suidan, H S, NICLOU, Simone P., Monard, D   +2 more
openaire   +4 more sources

Binding of a Thrombin Receptor Tethered Ligand Analogue to Human Platelet Thrombin Receptor

Molecular Pharmacology, 1997
A thrombin receptor-radioligand binding assay was developed using [3H]A(pF-F)R(ChA)(hR)Y-NH2 ([3H]haTRAP), a high affinity thrombin receptor-activating peptide (TRAP), and human platelet membranes. Scatchard analysis of saturation binding data indicated that [3H]haTRAP bound to platelet membranes with a Kd of 15 nM and a Bmax of 5.2 pmol/mg of protein.
H S, Ahn, C, Foster, G, Boykow, L, Arik, A, Smith-Torhan, D, Hesk, M, Chatterjee   +6 more
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The Role of Thrombin and Thrombin Receptors in the Brain

2008
The serine protease thrombin is generated from its zymogen prothrombin. Both thrombin and prothrombin have been detected locally in the brain. Emerging evidence demonstrates that thrombin exerts physiological and pathological functions in the central nervous system.
Weibo Luo, Yingfei Wang, Georg Reiser*
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